(S)-2-tert-Butoxycarbonylamino-propionic acid 2-tert-butoxycarbonylamino-ethyl ester | 113707-02-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-2-tert-Butoxycarbonylamino-propionic acid 2-tert-butoxycarbonylamino-ethyl ester
• 英文别名: 2-[(2-methylpropan-2-yl)oxycarbonylamino]ethyl (2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoate
• CAS: 113707-02-1
• 化学式: C₁₅H₂₈N₂O₆
• 分子量: 332.397
• InChiKey: LPCROSORTGCPNW-JTQLQIEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  23
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  103
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  N-叔丁氧羰基-L-丙氨酸 、 N-(叔丁氧羰基)乙醇胺 在 papain 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 24.0h， 以50%的产率得到(S)-2-tert-Butoxycarbonylamino-propionic acid 2-tert-butoxycarbonylamino-ethyl ester
  参考文献：
  名称：

  木瓜蛋白酶通过醇和二醇催化丙氨酸的酯化

  摘要：

  在双相条件下，研究了木瓜蛋白酶催化的Boc-Ala-OH与各种醇和二醇的酯化反应。长链二醇HO（CH 2）nOH在n = 10时具有良好的酯化收率，而同源醇C n H 2n + 1 OH仅在n = 2、4、6时能很好地冷凝。描述。

  DOI：

  10.1016/s0040-4039(00)95615-6

文献信息

• Diamine crosslinking agents, crosslinked acidic polysaccharides and medical materials
  申请人：Seikagaku Corporation

  公开号：US10919840B2

  公开（公告）日：2021-02-16

  The invention provides a diamine crosslinking agent for acidic polysaccharides consisting of a diamine compound having a primary amino group at both terminals and an ester or thioester bond in the molecule, wherein the number of atom in the linear chain between at least one of the amino groups and the carbonyl carbon in the ester or thioester is 1 to 5; in particular, a diamine crosslinking agent for acidic polysaccharides which is represented by the general formula (I) below: [the symbols in the formula are as described in the specification]; a crosslinked acidic polysaccharide obtained by forming crosslinks by amide bonding between the amino groups in the diamine crosslinking agent and carboxyl groups in an acidic polysaccharide; and a medical material including the crosslinked product.

  本发明提供了一种用于酸性多糖的二胺交联剂，该交联剂由二胺化合物组成，该二胺化合物的两个末端均有伯氨基，分子中具有酯键或硫酯键，其中至少一个氨基与酯键或硫酯键中的羰基碳之间的线性链上的原子数为 1 至 5；特别是一种用于酸性多糖的二胺交联剂，该交联剂由以下通式（I）表示： [式中符号如说明书所述]；通过二胺交联剂中的氨基与酸性多糖中的羧基之间的酰胺键形成交联而获得的交联酸性多糖；以及包括交联产物的医用材料。
• DIAMINE CROSSLINKING AGENTS, CROSSLINKED ACIDIC POLYSACCHARIDES AND MEDICAL MATERIALS
  申请人：Seikagaku Corporation

  公开号：US20190345312A1

  公开（公告）日：2019-11-14

  The invention provides a diamine crosslinking agent for acidic polysaccharides consisting of a diamine compound having a primary amino group at both terminals and an ester or thioester bond in the molecule, wherein the number of atom in the linear chain between at least one of the amino groups and the carbonyl carbon in the ester or thioester is 1 to 5; in particular, a diamine crosslinking agent for acidic polysaccharides which is represented by the general formula (I) below: [the symbols in the formula are as described in the specification]; a crosslinked acidic polysaccharide obtained by forming crosslinks by amide bonding between the amino groups in the diamine crosslinking agent and carboxyl groups in an acidic polysaccharide; and a medical material including the crosslinked product.