E-ethyl-2-methyl-3-fluoroacrylate | 100905-60-0

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 乙烯基卤化物
• 英文名称: E-ethyl-2-methyl-3-fluoroacrylate
• 英文别名: ethyl 2-methyl-3-fluoroacrylate；(E)-Ethyl 2-Methyl-3-fluoroacrylate；ethyl (E)-3-fluoro-2-methylprop-2-enoate
• CAS: 100905-60-0
• 化学式: C₆H₉FO₂
• 分子量: 132.135
• InChiKey: SNYQOMVJLLQNCV-SNAWJCMRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  E-ethyl-2-methyl-3-fluoroacrylate 生成 2-methyl-3-fluoroallyl alcohol
  参考文献：
  名称：

  MCDONALD, IAN A.

  摘要：

  DOI：
• 作为产物：
  描述：

  tert-butyl 2-difluoromethyl-2-carbethoxypropionate 在 三氟乙酸 、 四氯化碳 作用下， 以 三氟乙酸 为溶剂， 生成 E-ethyl-2-methyl-3-fluoroacrylate
  参考文献：
  名称：

  Fluoroallylamine derivatives

  摘要：

  以下公式I的氟烯丙胺衍生物是新型的MAO-抑制剂，在低剂量下选择性地抑制MAO-B： ##STR1## 其中：R.sub.1和R.sub.2独立地代表氢、氯或氟；R.sub.3代表氢或（C.sub.1-C.sub.4）烷基；X代表氧或硫。它们可用于治疗抑郁症，并与L-多巴一起用于帕金森症的治疗。

  公开号：

  US04699928A1

文献信息

• Amine-based and amide-based inhibitors of semicarbazide-sensitive amine oxidase (SSAO)enzyme activity and VAP-1 mediated adhesion useful for treatment of diseases
  申请人：Salter-Cid M. Luisa

  公开号：US20070078157A1

  公开（公告）日：2007-04-05

  Compositions and methods are disclosed for inhibiting semicarbazide-sensitive amine oxidase (SSAO), also known as vascular adhesion protein-1 (VAP-1). The compounds disclosed are amine-containing and amide-containing compounds. The compounds and compositions are useful for treatment of diseases, including inflammation, inflammatory diseases and autoimmune disorders.

  本发明公开了抑制半卡巴肼敏感性胺氧化酶（SSAO），也称为血管黏附蛋白-1（VAP-1）的组合物和方法。所公开的化合物是含有胺基和酰胺基的化合物。这些化合物和组合物可用于治疗炎症、炎症性疾病和自身免疫性疾病等疾病。
• A general preparation of fluoroallylamine enzyme inhibitors incorporating a β-substituted heteroatom
  作者：Ian A. McDonald、Philippe Bey

  DOI：10.1016/s0040-4039(00)89256-4

  日期：1985.1
• PARTICLES COMPRISING AMPHIPHILIC COPOLYMERS, HAVING A CROSS-LINKED SHELL DOMAIN AND AN INTERIOR CORE DOMAIN, USEFUL FOR PHARMACEUTICAL AND OTHER APPLICATIONS
  申请人：G.D. Searle & Co.

  公开号：EP0907666A1

  公开（公告）日：1999-04-14
• POLYMERS CONTAINING SILOXANE MONOMERS
  申请人：Ding Ni

  公开号：US20080262606A1

  公开（公告）日：2008-10-23

  A polymer of siloxanes as flexibility monomers and strength monomers is provided. It is also provided a polymer blend that contains a polymer formed of siloxane monomers and strength monomers and another biocompatible polymer. The biocompatible polymer or polymer blend described herein and optionally a bioactive agent can form a coating on an implantable device such as a drug-delivery stent. The implantable device can be used for treating or preventing a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.
• US4699928A
  申请人：——

  公开号：US4699928A

  公开（公告）日：1987-10-13