2-bromo-4-((oxiran-2-ylmethoxy)methyl)furan | 1346519-82-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-bromo-4-((oxiran-2-ylmethoxy)methyl)furan
• CAS: 1346519-82-1
• 化学式: C₈H₉BrO₃
• 分子量: 233.062
• InChiKey: SRFBFMRDUOKWJP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.96
• 重原子数：
  12.0
• 可旋转键数：
  4.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  34.9
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  辛胺 、 2-bromo-4-((oxiran-2-ylmethoxy)methyl)furan 以 甲醇 为溶剂， 以54%的产率得到1-((5-bromofuran-3-yl)methoxy)-3-(octylamino)propan-2-ol
  参考文献：
  名称：

  Synthesis and Antibacterial Activity of Aromatic and Heteroaromatic Amino Alcohols

  摘要：

  Two series of aromatic and heteroaromatic amino alcohols were synthesized from alcohols and aldehydes and evaluated for their antibacterial activities. All the octylated compounds displayed a better activity against the four bacteria tested when evaluated by the agar diffusion method and were selected for the evaluation of minimal inhibitory concentration. The best results were obtained for p‐octyloxybenzyl derivatives against Staphylococcus epidermidis (minimal inhibitory concentrations = 32 μm).

  DOI：

  10.1111/j.1747-0285.2011.01231.x
• 作为产物：
  描述：

  5-bromo-3-furylmethanol 、 环氧氯丙烷 在 四丁基溴化铵 、 sodium hydroxide 作用下， 以 水 为溶剂， 反应 24.0h， 生成 2-bromo-4-((oxiran-2-ylmethoxy)methyl)furan
  参考文献：
  名称：

  Synthesis and Antibacterial Activity of Aromatic and Heteroaromatic Amino Alcohols

  摘要：

  Two series of aromatic and heteroaromatic amino alcohols were synthesized from alcohols and aldehydes and evaluated for their antibacterial activities. All the octylated compounds displayed a better activity against the four bacteria tested when evaluated by the agar diffusion method and were selected for the evaluation of minimal inhibitory concentration. The best results were obtained for p‐octyloxybenzyl derivatives against Staphylococcus epidermidis (minimal inhibitory concentrations = 32 μm).

  DOI：

  10.1111/j.1747-0285.2011.01231.x