Ala-Gly-Gly-His-OMe | 133342-23-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Ala-Gly-Gly-His-OMe
• CAS: 133342-23-1
• 化学式: C₁₄H₂₂N₆O₅
• 分子量: 354.366
• InChiKey: SHACXKXPGFJMEV-WPRPVWTQSA-N

反应信息

• 作为反应物：
  描述：

  铜 、 Ala-Gly-Gly-His-OMe 以 水 为溶剂， 生成
  参考文献：
  名称：

  A study of the comparative donor properties to Cu II of the terminal amino and imidazole nitrogens in peptides

  摘要：

  The synthesis of the tetrapeptides Ala-Gly-Gly-His, Boc-Ala-Gly-Gly-His (Boc = t-butoxycarbonyl), Ala-Gly-Gly-His(pi-bom) (pi-bom = N-pi-benzoxymethyl), Ala-Gly-Gly-His-OMe, and Ala-Gly-Pro-His is reported, together with the results of a pH-metric and spectroscopic (absorption, c.d., and e.s.r.) study of their complexes with H+ and Cu(ll). The work was designed to study the initial site of binding to Cu(ll) in peptides containing both a terminal amino nitrogen and a histidyl residue. Results show that the pi-N of the imidazole ring of the histidyl residue is the primary anchoring site for copper (ll) co-ordination, and that the next nitrogen to bond can be the terminal amino N, forming a macrocyclic chelate ring.

  DOI：

  10.1039/dt9900003565