N4-{[4-(aminomethyl)cyclohexyl]methyl}-5-nitro-N2-(pyridin-3-ylmethyl)pyrimidine-2,4-diamine | 736052-86-1

• 分子结构分类: 有机化合物 - 有机1,3-偶极化合物 - 烯丙基型1,3-偶极有机化合物
• 英文名称: N4-{[4-(aminomethyl)cyclohexyl]methyl}-5-nitro-N2-(pyridin-3-ylmethyl)pyrimidine-2,4-diamine
• 英文别名: 4-N-[[4-(aminomethyl)cyclohexyl]methyl]-5-nitro-2-N-(pyridin-3-ylmethyl)pyrimidine-2,4-diamine
• CAS: 736052-86-1
• 化学式: C₁₈H₂₅N₇O₂
• 分子量: 371.442
• InChiKey: OJCIPWHNXSKZBZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  27
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  135
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• Stem Cell Modulation II
  申请人：UNIVERSITY OF CANBERRA

  公开号：US20160354367A1

  公开（公告）日：2016-12-08

  Disclosed are methods and compositions for modulating cancer stem cells. More particularly, the present invention discloses the use of protein kinase C theta inhibitors (PKC-θ) for inhibiting the growth of PKC-θ-overexpressing cells including cancer stem cells, for enhancing the biological effects of chemotherapeutic drugs or irradiation on cancer cells, for treating cancer, including metastatic cancer and/or for preventing cancer recurrence.
• US7550473B2
  申请人：——

  公开号：US7550473B2

  公开（公告）日：2009-06-23