1-(furan-2-yl)-N-[2-(furan-2-ylmethylideneamino)ethyl]methanimine | 4114-95-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 英文名称: 1-(furan-2-yl)-N-[2-(furan-2-ylmethylideneamino)ethyl]methanimine
• 英文别名: N,N'-bis(furfuryliden)-1,2-ethylenediamine；N,N'-Difurfurylideneethylenediamine；N,N'-difurfuryliden-ethylenediamine；N,N'-Difurfuryliden-aethylendiamin
• CAS: 4114-95-8
• 化学式: C₁₂H₁₂N₂O₂
• 分子量: 216.239
• InChiKey: KWTGUBIXDKCLIY-UTLPMFLDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.41
• 重原子数：
  16.0
• 可旋转键数：
  5.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  51.0
• 氢给体数：
  0.0
• 氢受体数：
  4.0

安全信息

• 海关编码：
  2932190090

反应信息

• 作为反应物：
  描述：

  1-(furan-2-yl)-N-[2-(furan-2-ylmethylideneamino)ethyl]methanimine 在 甲醇 、 铂 作用下， 生成 N,N'-bis[(2-furyl)methyl]-1,2-diaminoethane
  参考文献：
  名称：

  Tanaka; Asami, Journal of the Scientific Research Institute, Tokyo, 1954, vol. 48, p. 202,205

  摘要：

  DOI：
• 作为产物：
  描述：

  糠醛 、 乙二胺 生成 1-(furan-2-yl)-N-[2-(furan-2-ylmethylideneamino)ethyl]methanimine
  参考文献：
  名称：

  Rameau, Recueil des Travaux Chimiques des Pays-Bas, 1938, vol. 57, p. 194,196

  摘要：

  DOI：

文献信息

• Ligand dependence of molybdenum-catalyzed alkylations. Molybdenum-isonitrile complexes as a new class of highly reactive alkylation catalysts
  作者：Barry M. Trost、Craig A. Merlic

  DOI：10.1021/ja00182a018

  日期：1990.12

  generates the most effective molybdenum catalysts known to date. The reactive catalyst proved to be Mo(RNC) 4 (CO) 2 . With this new catalyst, a much broader range of substrates can be employed including many that failed or reacted very poorly by using molybdenum hexacarbonyl. The regioselectivity also differs from that obtained with molybdenum hexacarbonyl. The stereochemistry of the reaction proceeds with

  已经制备了一系列带有-α-二亚胺、N,N'-二亚芳基乙二胺和异腈配体的钼配合物，并评估了它们通过使用乙酸烯丙酯，尤其是烯丙基砜催化烷基化的能力。与bpyMo(CO) 4 相比，(bpy)Mo(CH 3 CN)(CO) 3 被证明是一种非常有效的催化剂。将异腈配体添加到六羰基钼上可产生迄今为止已知的最有效的钼催化剂。反应性催化剂被证明是Mo(RNC) 4 (CO) 2 。使用这种新催化剂，可以使用更广泛的底物，包括许多因使用六羰基钼而失效或反应非常差的底物。区域选择性也不同于使用六羰基钼获得的区域选择性。即使在产生与六羰基钼的非对映异构体混合物的条件下，反应的立体化学也以非常干净的净保留构型进行。提出了一种解释看似不同的催化剂复合物的机械原理
• Diastereoselective Synthesis of Piperazines by Manganese-Mediated Reductive Cyclization
  作者：Gregory J. Mercer、Matthew S. Sigman

  DOI：10.1021/ol034469l

  日期：2003.5.1

  A simple and effective synthesis of trans aryl-substituted piperazines using a Bronsted acid and manganese(0) is described. [reaction: see text]

  描述了一种使用布朗斯台德酸和锰（0）的简单有效的合成反式芳基取代的哌嗪的方法。[反应：看文字]
• Cobalt(II)-Catalyzed Conversion of Allylic Alcohols/Acetates to Allylic Amides in the Presence of Nitriles
  作者：Manoj Mukhopadhyay、M. Madhava Reddy、G. C. Maikap、Javed Iqbal

  DOI：10.1021/jo00114a013

  日期：1995.5

  Various secondary allylic alcohols or their acetates and tertiary allylic alcohols can be converted to the corresponding transposed allylic amides in the presence of a catalytic quantity of cobalt(II) chloride and acetic anhydride in acetonitrile. Tertiary alcohols undergo complete rearrangement whereas secondary ones afford a mixture of regioisomers. Moderate yields of amides are also obtained by reacting acrylonitrile with secondary alcohols in 1,2-dichloroethane. The presence of acetic anhydride or acetic acid is crucial to the formation of amides as the absence of the former affords no amides and the allylic alcohols are mainly recovered as regioisomeric mixtures. The regioselectivity during amide formation can be enhanced by using cobalt complexes 14-16 in acetic acid medium. Some preliminary studies indicate that these reactions are proceeding via an pi-allyl complex or tight ion pair rather than a [3,3] sigmatropic rearrangement of acetamidate obtained in a Pinner reaction.
• Shukla, P. R.; Takroo, Renu, Indian Journal of Chemistry, Section A: Inorganic, Physical, Theoretical and Analytical, 1981, vol. 20, # 3, p. 305 - 307
  作者：Shukla, P. R.、Takroo, Renu

  DOI：——

  日期：——
• Penicillin salts of substituted alkylene diamines
  申请人：WYETH CORP

  公开号：US02627491A1

  公开（公告）日：1953-02-03