2-methoxycarbonyl-3,3,3-trifluorothiopropionyl fluoride | 651719-50-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-methoxycarbonyl-3,3,3-trifluorothiopropionyl fluoride
• 英文别名: Methyl 3,3,3-trifluoro-2-(fluorocarbonothioyl)propanoate；methyl 2-carbonofluoridothioyl-3,3,3-trifluoropropanoate
• CAS: 651719-50-5
• 化学式: C₅H₄F₄O₂S
• 分子量: 204.145
• InChiKey: MZHSIDNLHHHCCV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  58.4
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  tert-butyl 1,3,3,3-tetrafluoro-2-methoxycarbonylpropenyl sulfide 在 phosphorus pentoxide 作用下， 反应 0.17h， 以20%的产率得到methoxycarbonyltrifluoromethylthioketene
  参考文献：
  名称：

  摘要：

  A new method was developed for the synthesis of methoxycarbonyltrifluoromethylthioketene by thermal cleavage of tert-butyl 1,3,3,3-tetrafluoro-2-methoxycarbonylpropenyl sulfide in the presence Of P2O5. This thioketene was demonstrated to exhibit high reactivity in reactions with nucleophiles as well as in ene and diene syntheses.

  DOI：

  10.1023/a:1024781929253

文献信息

• ——
  作者：A. N. Kovregin、A. Yu. Sizov、A. F. Ermolov

  DOI：10.1023/a:1024781929253

  日期：——

  A new method was developed for the synthesis of methoxycarbonyltrifluoromethylthioketene by thermal cleavage of tert-butyl 1,3,3,3-tetrafluoro-2-methoxycarbonylpropenyl sulfide in the presence Of P2O5. This thioketene was demonstrated to exhibit high reactivity in reactions with nucleophiles as well as in ene and diene syntheses.