1-(3-bromophenyl)-5-(1H-pyrazol-5-yl)benzimidazole | 951655-35-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 1-(3-bromophenyl)-5-(1H-pyrazol-5-yl)benzimidazole
• CAS: 951655-35-9
• 化学式: C₁₆H₁₁BrN₄
• 分子量: 339.194
• InChiKey: LQGSDPUPLSOHNK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-[1-(3-bromophenyl)-1H-benzimidazol-5-yl]ethanone 在 肼 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 生成 1-(3-bromophenyl)-5-(1H-pyrazol-5-yl)benzimidazole
  参考文献：
  名称：

  WO2007/110374

  摘要：

  公开号：

文献信息

• [EN] SUBSITITUTED BENZIMIDAZOLES<br/>[FR] BENZIMIDAZOLES SUBSTITUÉS
  申请人：CONCERT PHARMACEUTICALS INC

  公开号：WO2011047315A1

  公开（公告）日：2011-04-21

  This invention relates to novel substituted benzimidazoles and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a compound that modulates theGABAA receptor. This invention also provides novel intermediates for the preparation of the compounds of the invention, and salts thereof.

  这项发明涉及新型取代苯并咪唑及其药用盐。该发明还提供了包括本发明化合物的组合物，并且利用这些组合物在治疗通过给予调节GABAA受体的化合物而有益治疗的疾病和症状的方法。该发明还提供了用于制备本发明化合物及其盐的新型中间体。
• BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABAA RECEPTOR COMPLEX
  申请人：Larsen Janus S.

  公开号：US20090036476A1

  公开（公告）日：2009-02-05

  This invention relates to novel benzimidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are useful in the treatment of central nervous system diseases and disorders which are responsive to modulation of the GABA A receptor complex, and in particular for combating anxiety and related diseases.

  本发明涉及新型苯并咪唑衍生物、含有这些化合物的药物组合物以及使用这些药物组合物进行治疗的方法。本发明的化合物对于治疗对GABAA受体复合物调节敏感的中枢神经系统疾病和障碍，尤其是对抗焦虑和相关疾病非常有用。
• Benzimidazole derivatives and their use for modulating the GABAa receptor complex
  申请人：NeuroSearch AS

  公开号：EP2319837A1

  公开（公告）日：2011-05-11

  This invention relates to novel benzimidazole derivatives of formula (I), pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are useful in the treatment of central nervous system diseases and disorders which are responsive to modulation of the GABAA receptor complex, and in particular for combating anxiety and related diseases.

  本发明涉及式（I）的新型苯并咪唑衍生物、含有这些化合物的药物组合物以及用其治疗的方法。 本发明的化合物可用于治疗对 GABAA 受体复合物的调节有反应的中枢神经系统疾病和失调，特别是用于防治焦虑症和相关疾病。
• Substituted Benzimidazoles
  申请人：Liu Julie F.

  公开号：US20110172280A1

  公开（公告）日：2011-07-14

  This invention relates to novel substituted benzimidazoles and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a compound that modulates the GABA A receptor. This invention also provides novel intermediates for the preparation of the compounds of the invention, and salts thereof.
• US7902230B2
  申请人：——

  公开号：US7902230B2

  公开（公告）日：2011-03-08