4-[(2R)-2,3-二(棕榈酰氧基)丙氧基]-4-氧代丁酸 | 108032-13-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 中文名称: 4-[(2R)-2,3-二(棕榈酰氧基)丙氧基]-4-氧代丁酸
• 中文别名: 噻唑,4-乙炔基-2-甲基-
• 英文名称: 1,2-dipalmitoyl-sn-glycerol-3-O-succinic acid monoester
• 英文别名: 1,2-dipalmitoyl-sn-glycero-3-succinate；1,2-dipalmitoyl-sn-3-succinylglycerol；1,2-Dipalmitoyl-3-succinylglycerol；4-[(2R)-2,3-di(hexadecanoyloxy)propoxy]-4-oxobutanoic acid
• CAS: 108032-13-9
• 化学式: C₃₉H₇₂O₈
• 分子量: 668.996
• InChiKey: GNENAKXIVCYCIZ-PGUFJCEWSA-N

物化性质

• 沸点：
  691.0±34.0 °C(Predicted)
• 密度：
  0.987±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  14
• 重原子数：
  47
• 可旋转键数：
  39
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  116
• 氢给体数：
  1
• 氢受体数：
  8

安全信息

• 海关编码：
  2918990090
• WGK Germany：
  3

反应信息

• 作为反应物：
  描述：

  N,N'-二琥珀酰亚胺基碳酸酯 、 4-[(2R)-2,3-二(棕榈酰氧基)丙氧基]-4-氧代丁酸 在 4-二甲氨基吡啶 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以1.6 g的产率得到(R)-2,3-bis(palmitoyloxy)propyl (2,5-dioxopyrrolidin-1-yl) succinate
  参考文献：
  名称：

  [EN] LIPID COMPOSITIONS COMPRISING PEPTIDE-LIPID CONJUGATES
  [FR] COMPOSITIONS LIPIDIQUES COMPRENANT DES CONJUGUÉS PEPTIDE-LIPIDE

  摘要：

  A lipid composition containing a nucleic acid, wherein the lipid composition comprises a peptide-lipid conjugate, is provided. The peptide of the peptide-lipid conjugates can be from 4 to 52 amino acids in length. Methods of using the lipid composition in the in vivo delivery of nucleic acids are further provided.

  公开号：

  WO2022235972A1
• 作为产物：
  描述：

  丁二酸酐 、 1,2-二棕榈酰-sn-丙三醇 在 吡啶 作用下， 以 二氯甲烷 为溶剂， 以96%的产率得到4-[(2R)-2,3-二(棕榈酰氧基)丙氧基]-4-氧代丁酸
  参考文献：
  名称：

  Lipopeptides Incorporated into Supported Phospholipid Monolayers Have High Specific Activity at Low Incorporation Levels

  摘要：

  The ability to present cell adhesion molecule (CAM) ligands in controlled amounts on a culture surface would greatly facilitate the control of cell growth and differentiation. Supported lipid monolayer/bilayer systems have previously been developed that allow for presentation of CAM ligands for cell interaction; however, these systems have employed peptide loadings much higher than those used in poly(ethylene glycol) (PEG)-based immobilization systems. We report the development of synthetic methods that can be used for the efficient and versatile creation of many linear and cyclic lipid-linked peptide moieties. Using RGD-based peptides for the alpha5beta1 integrin as a model system, we have demonstrated that these lipopeptides support efficient cell binding and spreading at CAM ligand loadings as low as 0.1 mol %, which is well below that previously reported for supported lipid systems. Engineered lipopeptide-based surfaces offer unique presentation options not possible with other immobilization systems, and the high activity at low loadings we have shown here may be extremely useful in presenting multiple CAM ligands for studying cell growth, differentiation, and signaling.

  DOI：

  10.1021/ja048684o

文献信息

• Polyamide oligomers
  申请人：——

  公开号：US20020026027A1

  公开（公告）日：2002-02-28

  The present invention relates to new polyamide oligomers. These oligomers can be conjugated to lipids, nucleic acids, peptides, proteins, etc. The oligomer-lipid conjugates can be used to form liposomes, virusomes, micelles, etc., optionally containing drugs or biological agents. The polyamide oligomers are heterobifunctional allowing the attachment of other suitable ligand compounds (e.g., a targeting moiety). In addition, methods of use for the liposomes, virusomes, micelles, etc., are provided.

  本发明涉及新的聚酰胺寡聚体。这些寡聚体可以与脂质、核酸、肽、蛋白质等共轭。寡聚体-脂质共轭物可以用于形成脂质体、病毒体、胶束等，可选地含有药物或生物制剂。聚酰胺寡聚体是异双官能团的，可以连接其他适当的配体化合物（例如，靶向基团）。此外，还提供了脂质体、病毒体、胶束等的使用方法。
• Novel methods of imaging and treatment with targeted compositions
  申请人：——

  公开号：US20030157025A1

  公开（公告）日：2003-08-21

  Novel ultrasound methods comprising administering to a patient a targeted vesicle composition which comprises vesicles comprising a lipid, protein or polymer, encapsulating a gas, in combination with a targeting ligand, and scanning the patient using ultrasound. The scanning may comprise exposing the patient to a first type of ultrasound energy and then interrogating the patient using a second type of ultrasound energy. The targeting ligand preferably targets tissues, cells or receptors, including myocardial cells, endothelial cells, epithelial cells, tumor cells and the glycoprotein GPIIbIIIa receptor. The methods may be used to detect a thrombus, enhancement of an old or echogenic thrombus, low concentrations of vesicles and vesicles targeted to tissues, cells or receptors.

  新型超声波方法包括向患者施加含有脂质、蛋白质或聚合物的气囊组成的有针对性的气囊组合物，该气囊包含一种气体，并与一个靶向配体结合，然后使用超声波扫描患者。扫描可能包括将患者暴露于第一种超声波能量，然后使用第二种超声波能量对患者进行询问。靶向配体首选靶向组织、细胞或受体，包括心肌细胞、内皮细胞、上皮细胞、肿瘤细胞和糖蛋白GPIIbIIIa受体。该方法可用于检测血栓、旧血栓或回声增强、低浓度气囊和靶向组织、细胞或受体的气囊。
• Methods for ultrasound imaging involving the use of a contrast agent and multiple images and processing of same
  申请人：ImaRx Pharmaceutical Corp.

  公开号：US06231834B1

  公开（公告）日：2001-05-15

  Improved methods for providing an image of an internal region of a patient. Embodiments of the invention involve the administration to the patient of a contrast agent which comprises, in an aqueous carrier, a lipid, protein, polymer or surfactant, and a gas. The patient is scanned using ultrasound imaging to obtain a visible image of the region. In embodiments of the invention, the scanning step may comprise applying a first quantity of ultrasound energy to the patient to provide a first image, followed by the application substantially immediately thereafter of a second quantity of ultrasound energy to provide a second image. The first and second images are then processed. The methods are particularly useful for obtaining on-line images of the cardiovascular region which may be employed, for example, to diagnose the presence of diseased tissue in the cardiovascular region of a patient.

  提供患者内部区域图像的改进方法。该发明的实施方式涉及向患者注射对比剂，其在水载体中包含脂质、蛋白质、聚合物或表面活性剂和气体。使用超声成像对患者进行扫描，以获得该区域的可见图像。在该发明的实施方式中，扫描步骤可以包括向患者施加第一量的超声能量以提供第一图像，然后立即施加第二量的超声能量以提供第二图像。然后处理第一和第二图像。该方法特别适用于获得心血管区域的在线图像，例如可用于诊断患者心血管区域的疾病组织的存在。
• Lipid soluble steroid prodrugs
  申请人：Imarx Therapeutics, Inc.

  公开号：US06444660B1

  公开（公告）日：2002-09-03

  The present invention is directed to novel lipid soluble steroid prodrugs, compositions comprising steroid prodrugs, and uses of the same.

  本发明涉及新型脂溶性类固醇前药、含有类固醇前药的组合物以及其用途。
• Optoacoustic contrast agents and methods for their use
  申请人：Imarx Pharmaceutical Corp.

  公开号：US06123923A1

  公开（公告）日：2000-09-26

  The present invention generally relates to optoacoustic contrast agents and methods of diagnostic and therapeutic imaging using optoacoustic contrast agents.

  本发明通常涉及光声造影剂和使用光声造影剂进行诊断和治疗成像的方法。