N-mesityl-N-(2-(mesitylamino)ethyl)formamide | 1060651-06-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-mesityl-N-(2-(mesitylamino)ethyl)formamide
• 英文别名: N-[2-(2,4,6-trimethylanilino)ethyl]-N-(2,4,6-trimethylphenyl)formamide
• CAS: 1060651-06-0
• 化学式: C₂₁H₂₈N₂O
• 分子量: 324.466
• InChiKey: VNUDQILQNHIXOC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 二叔丁基过氧化物 、 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 6.0h， 生成 N-mesityl-N-(2-(mesitylamino)ethyl)formamide
  参考文献：
  名称：

  Imidazolium Salts: A Mild Reducing and Antioxidative Reagent

  摘要：

  The concept of directly using imidazolium salts (IMSs) as mild reducing and antioxidative reagents was proposed and investigated. A simple and robust protocol for the synthesis stable, ultrafine gold nanoparticles has been established using IMSs under mild IMSs showed remarkably lower toxicity but greater antioxidative power than N-acetyl-L-cystein and (-)-epigallocatechin gallate on HSC-T6 cells. These studies demonstrate that the simple and inexpensive IMSs represent a new type of antioxidant with potential biomedical applications.

  DOI：

  10.1021/ja8037883

文献信息

• The Facile Hydrolysis of Imidazolinium Chlorides (N‐Heterocyclic Carbene Precursors) Under Basic Aqueous Conditions
  作者：Nedra Touj、Jerwin Jay Taping、Nikolay Tumanov、Johan Wouters、Lionel Delaude

  DOI：10.1002/chem.202302402

  日期：2023.12

  The hydrolysis of imidazolinium chlorides takes place readily in a basic water/dichloromethane biphasic mixture at room temperature. Experimental conditions were optimized to afford full conversions and high yields of γ-aminoformamides starting from symmetrical or unsymmetrical substrates. Structural parameters that affect the resilience of these important NHC precursors in the presence of moisture

  氯化咪唑啉鎓在室温下的碱性水/二氯甲烷双相混合物中很容易发生水解。对实验条件进行了优化，以从对称或不对称底物开始获得完全转化和高产率的γ-氨基甲酰胺。研究了在湿气存在下影响这些重要 NHC 前体弹性的结构参数。特别强调了抗衡阴离子的关键影响。
• The influence of moisture on deprotonation mode of imidazolinium chlorides with palladacycle acetate dimer
  作者：M. Emin Günay、Namık Özdemir、Mahmut Ulusoy、Melih Uçak、Muharrem Dinçer、Bekir Çetinkaya

  DOI：10.1016/j.jorganchem.2009.02.023

  日期：2009.6

  Deprotonation of 1,3-diorganyl imidazolinium salts, 1, with N,C-type palladacyclic acetate dimer 2 afforded novel NHC coordinated complexes 3 along with ring opening hydrolysis products 4, which may coordinate to palladium center via NH group to give 5a. The hydrolysis necessitates the study of NHC complex formation in anhydrous media. The new compounds were characterized by spectroscopic methods and three of them (3c, 4c, 5a) by X-ray single-crystal diffraction studies. (C) 2009 Elsevier B. V. All rights reserved.