Ethyl α-methyl-N-methyl-2-pyrroleacetate | 60730-15-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: Ethyl α-methyl-N-methyl-2-pyrroleacetate
• 英文别名: ethyl 2-(1-methyl-2-pyrrolyl)-propionate；ethyl 2-(1-methylpyrrol-2-yl)propanoate
• CAS: 60730-15-6
• 化学式: C₁₀H₁₅NO₂
• 分子量: 181.235
• InChiKey: BYXVWIJUIQYESP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  31.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  ethyl 2-(1-methyl-2-pyrrolyl)-acrylate 以 乙醇 为溶剂， 生成 Ethyl α-methyl-N-methyl-2-pyrroleacetate
  参考文献：
  名称：

  Esters and amides of substituted pyrrole acetic acids

  摘要：

  取代吡咯乙酸的酯和酰胺在治疗结肠息肉方面是有用的。

  公开号：

  US05721347A1

文献信息

• [EN] MODULATORS OF THE GLUCOCORTICOID RECEPTOR<br/>[FR] MODULATEURS DU RECEPTEUR GLUCOCORTICOIDE
  申请人：PFIZER PROD INC

  公开号：WO2004005229A1

  公开（公告）日：2004-01-15

  The present invention provides compounds of the formula wherein A is of the formula and X, Y, n, R1-R25 are as described in the specification which are modulators of the glucocorticoid receptor and are thus useful for the treatment of animals requiring glucocorticoid receptor ágonist.therapy. Glucocorticoid-receptor modulators are useful in the treatment of certain inflammatory conditions.

  本发明提供了以下式中A为该式，X、Y、n、R1-R25如说明书中所述的化合物，这些化合物是糖皮质激素受体的调节剂，因此对需要糖皮质激素受体激动剂治疗的动物有用。糖皮质激素受体调节剂在治疗某些炎症性疾病中是有用的。
• Homolytic aromatic substitutions of pentatomic heteroaromatics with electrophilic carbon radicals generated by alkyl halides and triethylborane
  作者：Enrico Baciocchi、Ester Muraglia

  DOI：10.1016/s0040-4039(00)74072-x

  日期：1993.7

  An efficient homolytic aromatic substitution of pyroles, furan and thiophene by ·CH2CO2Et and ·CH(CH3)CO2Et has been carried out, the radicals being generated by autoxidation of BEt3 in the presence of XCH2CO2Et and XCH(CH3)CO2Et (X=Br, I).

  已经进行了·CH 2 CO 2 Et和·CH（CH 3）CO 2 Et对吡咯，呋喃和噻吩的有效均质芳族取代，自由基是在XCH 2 CO 2存在下通过BEt 3的自氧化产生的。Et和XCH（CH 3）CO 2 Et（X = Br，I）。
• Modulators of the glucocorticoid receptor
  申请人：Pfizer Inc.

  公开号：US20040138262A1

  公开（公告）日：2004-07-15

  The present invention provides compounds of the formula 1 wherein A is of the formula 2 and X, Y, n, R 1 -R 25 are as described in the specification which are modulators of the glucocorticoid receptor and are thus useful for the treatment of animals requiring glucocorticoid receptor agonist therapy. Glucocorticoid receptor modulators are useful in the treatment of certain inflammatory conditions.

  本发明提供了一些化合物，其化学式为1，其中A的化学式为2，X、Y、n、R1-R25如说明书所述，这些化合物是糖皮质激素受体调节剂，因此对需要糖皮质激素受体激动剂治疗的动物有用。糖皮质激素受体调节剂在治疗某些炎症病症方面是有用的。
• Modulators of the Glucocorticoid Receptor
  申请人：Chantigny A. Yves

  公开号：US20060247264A1

  公开（公告）日：2006-11-02

  The present invention provides compounds of the formula wherein A is of the formula and X, Y, n, R 1 —R 25 are as described in the specification which are modulators of the glucocorticoid receptor and are thus useful for the treatment of animals requiring glucocorticoid receptor agonist therapy. Glucocorticoid receptor modulators are useful in the treatment of certain inflammatory conditions.

  本发明提供了公式的化合物，其中A的公式为，X、Y、n、R1-R25如规范所述，它们是糖皮质激素受体的调节剂，因此对需要糖皮质激素受体激动剂治疗的动物有用。糖皮质激素受体调节剂在治疗某些炎症性疾病方面是有用的。
• Homolytic substitution reactions of electron-rich pentatomic heteroaromatics by electrophilic carbon-centered radicals. Synthesis of .alpha.-heteroarylacetic acids
  作者：Enrico Baciocchi、Ester Muraglia、Giancarlo Sleiter

  DOI：10.1021/jo00051a027

  日期：1992.12

  Efficient and selective homolytic substitutions (yields between 55 and 90%) of pyrrole, indole, and some pyrrole derivatives have been carried out using ambiphilic and electrophilic carbon centered radicals, generated in DMSO by Fe2+/H2O2 and alpha-cyano-, alpha-carbonyl-, and alpha,alpha'-dicarbonylalkyl iodides. The reaction is highly successful also with pyrroles substituted by electron-withdrawing groups, which has allowed an efficient synthesis of Tolmetin. A few extensions of this reaction to furan and thiophene are described.