3-(4-piperidinyloxy)phenol hydrochloride | 528861-48-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 3-(4-piperidinyloxy)phenol hydrochloride
• 英文别名: 3-Piperidin-4-yloxyphenol;hydrochloride
• CAS: 528861-48-5
• 化学式: C₁₁H₁₅NO₂*ClH
• 分子量: 229.707
• InChiKey: UWKBQIDXMFZSTG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.94
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  41.5
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• Amine derivative
  申请人：Abe Hidenori

  公开号：US20050245571A1

  公开（公告）日：2005-11-03

  The present invention provide a compound of the formula: wherein X and X′ are the same or different and each represents a hydrogen atom, etc.; R 1 and R 2 are the same or different and each represents a hydrogen atom, etc.; R 3 represents a hydrocarbon group optionally having substituents, etc.; R 4 represents a hydrogen atom, etc.; Y and Ya are the same or different and each represents a bond or a spacer having a main chain of 1 to 8 atoms; Z and Za are the same or different and each represents a hydrogen atom, etc.; or a salt thereof or a prodrug thereof, having a somatostatin receptor binding inhibitory activity and is useful for preventing and/or treating diseases associated with somatostatin.

  本发明提供一种化合物，其式为：其中X和X′相同或不同，每个代表氢原子等；R1和R2相同或不同，每个代表氢原子等；R3表示一个烃基，可选地具有取代基等；R4表示氢原子等；Y和Ya相同或不同，每个代表键或具有1至8个原子的主链的间隔物；Z和Za相同或不同，每个代表氢原子等；或其盐或前药，具有生长抑素受体结合抑制活性，并用于预防和/或治疗与生长抑素相关的疾病。
• Carbamic acid compounds comprising a piperazine linkage as hdac inhibitors
  申请人：Watkins J. Clare

  公开号：US20050143385A1

  公开（公告）日：2005-06-30

  This invention pertains to certain carbamic acid compounds which inhibit HDAC (histone deacetylase) activity of the following formula: wherein: Cy is independently a cyclyl group; Q 1 is independently a covalent bond or cyclyl leader group; the piperazin-1,4-diyl group is optionally substituted; J 1 is independently a covalent bond or —C(═;O)—; J 2 is independently —C(═O)— or —S(═O) 2 —; Q 2 is independently an acid leader group; wherein: Cy is independently: C 3-20 carbocyclyl, C 3-20 heterocyclyl, or C 5-20 aryl; and is optionally substituted; Q 1 is independently: a covalent bond; C 1-7 alkylene; or C 1-7 alkylene-X—C 1-7 alkylene, —X—C 1-7 alkylene, or C 1-7 alkylene-X—, wherein X is —O— or —S—; and is optionally substituted; Q 2 is independently: C 4-8 alkylene; and is optionally substituted; and has a backbone length of at least 4 atoms; or: Q 2 is independently: C 5-20 arylene; C 5-20 arylene-C 1-7 alkylene; C 1-7 alkylene-C 5-20 arylene; or, C 1-7 alkylene-C 5-20 arylene-C 1-7 alkylene; and is optionally substituted; and has a backbone length of at least 4 atoms; or a pharmaceutically acceptable salt, solvate, amide, ester, ether, chemically protected form, or prodrug thereof. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit HDAC, and in the treatment of conditions mediated by HDAC, cancer, proliferative conditions, psoriasis, etc.

  本发明涉及某些卡巴酸类化合物，其抑制以下式中的HDAC（组蛋白去乙酰化酶）活性：其中：Cy独立地是环烷基团；Q1独立地是共价键或环烷基团；哌嗪-1,4-二基基团可选择性取代；J1独立地是共价键或-C（═;O）-；J2独立地是-C（═O）-或-S（═O）2-；Q2独立地是酸性基团；其中：Cy独立地是C3-20碳环烷基、C3-20杂环烷基或C5-20芳基；并且可选择性取代；Q1独立地是：共价键；C1-7烷基；或C1-7烷基-X-C1-7烷基，-X-C1-7烷基或C1-7烷基-X-，其中X为-O-或-S-；并且可选择性取代；Q2独立地是C4-8烷基；并且可选择性取代；并且具有至少4个原子的骨架长度；或：Q2独立地是C5-20芳基、C5-20芳基-C1-7烷基、C1-7烷基-C5-20芳基或C1-7烷基-C5-20芳基-C1-7烷基；并且可选择性取代；并且具有至少4个原子的骨架长度；或其药学上可接受的盐、溶剂化合物、酰胺、酯、醚、化学保护形式或前药。本发明还涉及包含这样的化合物的制药组合物，以及这样的化合物和组合物的使用，无论是在体外还是体内，以抑制HDAC，并用于治疗由HDAC介导的疾病，如癌症、增殖性疾病、牛皮癣等。
• AMINE DERIVATIVE
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP1437351A1

  公开（公告）日：2004-07-14

  The present invention provide a compound of the formula: wherein X and X' are the same or different and each represents a hydrogen atom, etc.; R1 and R2 are the same or different and each represents a hydrogen atom, etc.; R3 represents a hydrocarbon group optionally having substituents, etc.; R4 represents a hydrogen atom, etc.; Y and Ya are the same or different and each represents a bond or a spacer having a main chain of 1 to 8 atoms; Z and Za are the same or different and each represents a hydrogen atom, etc.; or a salt thereof or a prodrug thereof, having a somatostatin receptor binding inhibitory activity and is useful for preventing and/or treating diseases associated with somatostatin.

  本发明提供一种式的化合物： 其中X和X'相同或不同，各自代表氢原子等；R1和R2相同或不同，各自代表氢原子等；R3代表任选具有取代基的烃基等；R4代表氢原子等。Y和Ya相同或不同，各自代表键或具有1至8个原子的主链的间隔物；Z和Za相同或不同，各自代表氢原子等；或其盐或其原药，具有抑制体生长抑素受体结合的活性，可用于预防和/或治疗与体生长抑素相关的疾病。