4-(2,3-dihydro-1H-inden-2-ylamino)-2-(3-(2-methoxyacetamido)phenylamino)-N-methylpyrimidine-5-carboxamide | 1254214-30-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 4-(2,3-dihydro-1H-inden-2-ylamino)-2-(3-(2-methoxyacetamido)phenylamino)-N-methylpyrimidine-5-carboxamide
• 英文别名: 4-(2,3-dihydro-1H-inden-2-ylamino)-2-[3-[(2-methoxyacetyl)amino]anilino]-N-methylpyrimidine-5-carboxamide
• CAS: 1254214-30-6
• 化学式: C₂₄H₂₆N₆O₃
• 分子量: 446.509
• InChiKey: IQDSPKVHCAURST-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  33
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  117
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• [EN] INHIBITORS OF JAK<br/>[FR] INHIBITEURS DE JAK
  申请人：PORTOLA PHARM INC

  公开号：WO2010129802A1

  公开（公告）日：2010-11-11

  The present invention is directed to compounds of formula (I) and tautomers and pharmaceutically acceptable salts thereof which are selective inhibitors of JAK. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition JAK activity, and methods to prevent or treat a number of conditions mediated at least in part by JAK activity.

  本发明涉及式(I)的化合物及其互变异构体和药学上可接受的盐，这些化合物是JAK的选择性抑制剂。本发明还涉及用于制备这种化合物的中间体，制备这种化合物，含有这种化合物的药物组合物，抑制JAK活性的方法，以及预防或治疗至少部分由JAK活性介导的多种疾病的方法。
• INHIBITORS OF JAK
  申请人：Portola Pharmaceuticals, Inc.

  公开号：US20130137673A1

  公开（公告）日：2013-05-30

  The present invention is directed to compounds of formula I and tautomers and pharmaceutically acceptable salts thereof which are selective inhibitors of JAK. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition JAK activity, and methods to prevent or treat a number of conditions mediated at least in part by JAK activity.

  本发明涉及公式I的化合物及其互变异构体和药学上可接受的盐，其为选择性JAK抑制剂。本发明还涉及制备此类化合物所使用的中间体、制备此类化合物的方法、包含此类化合物的药物组合物、抑制JAK活性的方法，以及预防或治疗至少部分由JAK活性介导的多种疾病的方法。
• US8367689B2
  申请人：——

  公开号：US8367689B2

  公开（公告）日：2013-02-05
• US8853230B2
  申请人：——

  公开号：US8853230B2

  公开（公告）日：2014-10-07