11-ddUTP | 439077-17-5

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷酸
• 英文名称: 11-ddUTP
• 英文别名: [[(2S,5R)-5-[5-[3-(6-aminohexanoylamino)prop-1-ynyl]-2,4-dioxopyrimidin-1-yl]oxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
• CAS: 439077-17-5
• 化学式: C₁₈H₂₉N₄O₁₄P₃
• 分子量: 618.368
• InChiKey: DPLLMPZLQGGVIU-GOEBONIOSA-N

物化性质

• 密度：
  1.67±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.46
• 重原子数：
  39.0
• 可旋转键数：
  14.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  279.03
• 氢给体数：
  7.0
• 氢受体数：
  12.0

反应信息

• 作为反应物：
  描述：

  11-ddUTP 、 在 4-二甲氨基吡啶 、 N,N'-二琥珀酰亚胺基碳酸酯 作用下， 生成
  参考文献：
  名称：

  FOUR COLOR FRET DYE NUCLEOTIDE TERMINATORS FOR DNA SEQUENCING

  摘要：

  The synthesis of four color set of energy transfer-dye terminators (8a-8d) starting from p-iodo-beta -phenylalanine was accomplished and their utility in the sequencing reactions has been evaluated.

  DOI：

  10.1081/ncn-100002348
• 作为产物：
  描述：

  5-(3-AMINO-1-PROPYNYL)-2',3'-DIDEOXYURIDINE 5'-TRIPHOSPHATE 、 2,5-Dioxo-1-pyrrolidinyl 6-aminohexanoate 生成 11-ddUTP
  参考文献：
  名称：

  FOUR COLOR FRET DYE NUCLEOTIDE TERMINATORS FOR DNA SEQUENCING

  摘要：

  The synthesis of four color set of energy transfer-dye terminators (8a-8d) starting from p-iodo-beta -phenylalanine was accomplished and their utility in the sequencing reactions has been evaluated.

  DOI：

  10.1081/ncn-100002348

文献信息

• [EN] NUCLEOTIDE ANALOGUES AND USE THEREOF FOR NUCLEIC ACID SEQUENCING AND ANALYSIS<br/>[FR] ANALOGUES NUCLÉOTIDIQUES ET LEUR UTILISATION POUR LE SÉQUENÇAGE ET L'ANALYSE D'ACIDES NUCLÉIQUES
  申请人：UNIV COLUMBIA

  公开号：WO2019178393A9

  公开（公告）日：2019-10-24
• Unnatural amino acid derived FRET cassettes, terminators and their DNA sequencing potential
  作者：Satyam Nampalli、Weihong Zhang、T Sudhakar Rao、Haiguang Xiao、Lakshmi P Kotra、Shiv Kumar

  DOI：10.1016/s0040-4039(02)00196-x

  日期：2002.3

  An unnatural, tri-functional amino acid. t-BOC-L-para-amino-phenylalanine (1). was utilized in the design and syntheses of highly efficient FRET cassettes (4-7) and converted them into 2'.3'-dideoxynucleotide terminators (8-11) for investigating DNA sequencing potential coupled with a thermostable DNA polymerase. Thermo Sequenase(TM) II . (C) 2002 Elsevier Science Ltd. All rights reserved.