2-(4-Chlor-phenyl)-1-methyl-5-amino-benzimidazol | 21444-79-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 2-(4-Chlor-phenyl)-1-methyl-5-amino-benzimidazol
• 英文别名: 2-(4-chloro-phenyl)-1-methyl-1H-benzoimidazol-5-ylamine；2-(4-Chlorophenyl)-1-methylbenzimidazol-5-amine
• CAS: 21444-79-1
• 化学式: C₁₄H₁₂ClN₃
• 分子量: 257.722
• InChiKey: NRDLAFYGTJNBPF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  43.8
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(4-Chlor-phenyl)-1-methyl-5-amino-benzimidazol 在 copper(I) oxide 、 盐酸 、 sodium nitrite 作用下， 生成 5-chloro-2-(4-chlorophenyl)-1-methyl-1H-benzimidazole
  参考文献：
  名称：

  Synthesis of a group of 1H--benzimidazoles and their screening for antiinflammatory activity

  摘要：

  DOI：

  10.1016/0223-5234(96)89560-2

文献信息

• Amide derivatives and pharmaceutically acceptable salts thereof, preparation method thereof and medicinal application thereof
  申请人：Shanghai Hengrui Pharmaceutical Co., Ltd.

  公开号：US10081629B2

  公开（公告）日：2018-09-25

  Amide derivatives and pharmaceutically acceptable salts thereof, preparation method thereof and medicinal application thereof are provided. Specifically, amide derivatives represented by general formula (I) are provided. The amide derivatives represented by general formula (I) can be used as a therapeutic agent, particularly as an inhibitor for microsomal prostaglandin E synthase-1 (mPGES-1), and also to treat and/or prevent diseases or illnesses such as inflammation and/or pain etc. The definition of each substituent group in general formula (I) is the same as the definition in the description.

  本发明提供了酰胺衍生物及其药学上可接受的盐、制备方法和药物应用。具体而言，本发明提供了通式（I）代表的酰胺衍生物。通式（I）代表的酰胺衍生物可用作治疗剂，特别是作为微粒体前列腺素 E 合酶-1（mPGES-1）的抑制剂，还可用于治疗和/或预防炎症和/或疼痛等疾病。通式（I）中各取代基的定义与说明中的定义相同。
• [EN] AMIDE DERIVATIVES AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PREPARATION METHOD THEREFOR AND MEDICINAL APPLICATION THEREOF<br/>[FR] DÉRIVÉS D'AMIDES ET LEURS SELS PHARMACEUTIQUEMENT ACCEPTABLES, LEUR PROCÉDÉ DE PRÉPARATION ET LEUR UTILISATION MÉDICALE<br/>[ZH] 酰胺类衍生物及其可药用盐、其制备方法及其在医药上的应用
  申请人：SHANGHAI HENGRUI PHARM CO LTD

  公开号：WO2015158204A1

  公开（公告）日：2015-10-22

  本发明涉及酰胺类衍生物及其可药用盐、其制备方法及其在医药上的应用。具体而言，本发明涉及一种通式（I）所示酰胺类衍生物、其制备方法及含有该衍生物的药物组合物，以及其作为治疗剂，特别是作为微粒体前列腺素E合成酶-1（mPGES-1）抑制剂的用途和其在制备治疗和/或预防炎症和/或疼痛等疾病或病症的药物中的用途，其中通式（I）中的各取代基的定义与说明书中的定义相同。
• AMIDE DERIVATIVES AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PREPARATION METHOD THEREFOR AND MEDICINAL APPLICATION THEREOF
  申请人：Shanghai Hengrui Pharmaceutical Co. Ltd.

  公开号：EP3133068B1

  公开（公告）日：2020-11-25
• AMIDE DERIVATIVES AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PREPARATION METHOD THEREOF AND MEDICINAL APPLICATION THEREOF
  申请人：Shanghai Hengrui Pharmaceutical Co., Ltd.

  公开号：US20170037044A1

  公开（公告）日：2017-02-09

  Amide derivatives and pharmaceutically acceptable salts thereof, preparation method thereof and medicinal application thereof are provided. Specifically, amide derivatives represented by general formula (I) are provided. The amide derivatives represented by general formula (I) can be used as a therapeutic agent, particularly as an inhibitor for microsomal prostaglandin E synthase-1 (mPGES-1), and also to treat and/or prevent diseases or illnesses such as inflammation and/or pain etc. The definition of each substituent group in general formula (I) is the same as the definition in the description.