1-(o-Methylbenzyl)-3,1-benzoxazin-2,4(1H)-dion | 57384-91-5

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: 1-(o-Methylbenzyl)-3,1-benzoxazin-2,4(1H)-dion
• 英文别名: 1-(4-methyl-benzyl)-1H-benzo[d][1,3]oxazine-2,4-dione；1-[(4-Methylphenyl)methyl]-3,1-benzoxazine-2,4-dione
• CAS: 57384-91-5
• 化学式: C₁₆H₁₃NO₃
• 分子量: 267.284
• InChiKey: NNFWIPMFLWTCJO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(o-Methylbenzyl)-3,1-benzoxazin-2,4(1H)-dion 在 盐酸羟胺 、 sodium hydroxide 作用下， 以 乙醇 、 水 为溶剂， 反应 0.08h， 生成
  参考文献：
  名称：

  Ph3P-I2介导的异羟肟酸反应直接合成N-单取代苯并咪唑-2-酮

  摘要：

  报道了一种通过Ph 3 P-I 2促进的异羟肟酸反应合成苯并咪唑酮的简便方法。在 O 活化异羟肟酸的 Lossen 型重排后，原位生成的异氰酸酯受到邻N-亲核试剂的分子内攻击，在温和条件下以良好的收率产生环化产物。该方法允许使用易于获得的起始材料和具有广泛底物范围的低成本试剂直接制备 N-单取代衍生物的单一区域异构体。

  DOI：

  10.1055/s-0040-1719897
• 作为产物：
  描述：

  靛红酸酐 、 alkaline earth salt of/the/ methylsulfuric acid 生成 1-(o-Methylbenzyl)-3,1-benzoxazin-2,4(1H)-dion
  参考文献：
  名称：

  2 H -3,1-苯并恶嗪-2,4（1 H）二酮（isatoic酐）的化学反应1. N-取代的2 H -3,1-苯并恶嗪-2,4（1 H）二酮的合成

  摘要：

  三种制备N-取代的2 H -3,1-苯并恶嗪-2,4（1 H）二酮（乙酸酐）的方法（1）使用2-氯-，2-硝基苯甲酸和N-未取代的等角酸酐作为制备方法描述了起始材料。

  DOI：

  10.1002/jhet.5570120325

文献信息

• HARDTMANN G. E.; KOLETAR G.; PFISTER O. R.; GOGERTY J. H.; IORIO L. C., J. MED. CHEM. <JMCM-AR>, 1975, 18, NO 5, 447-453
  作者：HARDTMANN G. E.、 KOLETAR G.、 PFISTER O. R.、 GOGERTY J. H.、 IORIO L. C.

  DOI：——

  日期：——
• N(14)-substituted evodiamine derivatives as dual topoisomerase 1/tubulin-Inhibiting anti-gastrointestinal tumor agents
  作者：Jiedan Deng、Lin Long、Xue Peng、Weifan Jiang、Ying Peng、Xi Zhang、Yuting Zhao、Ying Tian、Zhen Wang、Linsheng Zhuo

  DOI：10.1016/j.ejmech.2023.115366

  日期：2023.7
• Novel Adducts Useful As Cure Components For Anaerobic Curable Compositions
  申请人：Messana Andrew D.

  公开号：US20090025874A1

  公开（公告）日：2009-01-29

  The present invention relates to novel polymer-bound adducts useful as cure components for anaerobic curable compositions. The compositions are particularly useful as adhesives and sealants.
• Scavenger supports and the use thereof in a process for the extraction of metals
  申请人：Pears David Alan

  公开号：US20090023604A1

  公开（公告）日：2009-01-22

  There is provided a process for removing metal from solution wherein a solution comprising a metal is contacted with a scavenger support, whereby the scavenger support binds to at least some of the metal in solution thereby decreasing the amount of metal in solution, characterised in that the scavenger support comprises a functionalised support comprising pendant groups selected from 1,3-ketoesters or 1,3-ketoamides or mixtures thereof attached to a support wherein a number of the pendant groups are reacted with an amine. Scavenger supports comprising a functionalised support comprising pendant 1,3-ketoester or 1,3-ketoamide groups of formula 1: wherein R 1 is an optionally substituted hydrocarbyl, perhalogenated hydrocarbyl or heterocyclyl group; X is O or NR 2 , wherein the free valence of O or NR 2 is bonded to a support optionally via a linker; and R 2 is hydrogen, an optionally substituted hydrocarbyl, or heterocyclyl group, wherein a number of the pendant groups are reacted with an amine are also provided. Preferred scavenger supports include scavenger supports comprising pendant 3-iminoesters, 3-iminoamides, 2,3-enaminoesters or 2,3-enaminoamides pendant groups of Formula (3) or (4): wherein R 1 is an optionally substituted hydrocarbyl, perhalogenated hydrocarbyl or heterocyclyl group; X is O or NR 2 , wherein the free valence of O or NR 2 is bonded to a support optionally via a linker; R 2 is hydrogen, an optionally substituted hydrocarbyl, or heterocyclyl group; R 4 is a substituent group; and R 5 is hydrogen or a substituent group, or R 4 and R 5 may optionally be linked in such a way so as to form an optionally substituted heterocyclic ring, or tautomers or salts thereof.
• SCAVENGER SUPPORTS AND THE USE THEREOF IN A PROCESS FOR THE EXTRACTION OF METALS
  申请人：Pears David Alan

  公开号：US20120211439A1

  公开（公告）日：2012-08-23

  A scavenger support and a process for removing metal from solution by contacting the solution with the scavenger support, whereby the scavenger support binds to at least some of the metal in solution thereby decreasing the amount of metal in solution. The scavenger support is a functionalised support having pendant groups selected from 1,3-ketoesters or 1,3-ketoamides or mixtures thereof having a structure according to formula 1, wherein a number of the pendant groups are reacted with an amine: wherein R 1 is an optionally substituted hydrocarbyl, perhalogenated hydrocarbyl or heterocyclyl group; X is O or NR 2 , wherein the free valence of O or NR 2 is bonded to a support optionally via a linker; and R 2 is hydrogen, an optionally substituted hydrocarbyl, or heterocyclyl group.