(E)-3-(1,3-dimethyl-2,4-dioxopyrimidin-5-yl)prop-2-enenitrile | 109856-20-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: (E)-3-(1,3-dimethyl-2,4-dioxopyrimidin-5-yl)prop-2-enenitrile
• CAS: 109856-20-4
• 化学式: C₉H₉N₃O₂
• 分子量: 191.189
• InChiKey: RZJXDNOMMLYYIW-ONEGZZNKSA-N

物化性质

• 熔点：
  165-166 °C(Solv: ethanol (64-17-5))
• 沸点：
  297.1±50.0 °C(Predicted)
• 密度：
  1.345±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  64.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  5-羟基-1,3-二甲基嘧啶-2,4-二酮 在 palladium dichloride 三乙胺 、 三苯基膦 作用下， 以 吡啶 、 N,N-二甲基甲酰胺 为溶剂， 反应 5.0h， 生成 (E)-3-(1,3-dimethyl-2,4-dioxopyrimidin-5-yl)prop-2-enenitrile
  参考文献：
  名称：

  Palladium Catalyzed Coupling of 5-Hydroxyuracil Trifluoromethanesulfonates (Triflates) with Alkenes and Alkynes

  摘要：

  DOI：

  10.3987/r-1987-02-0355

文献信息

• A Simple Synthesis of 5-(1-Alkenyl)uracil Derivatives by Palladium-Catalyzed Oxidative Coupling of Uracils With Olefins
  作者：Kosaku Hirota、Yoshiaki Isobe、Yukio Kitade、Yoshifumi Maki

  DOI：10.1055/s-1987-27981

  日期：——

  The oxidative coupling of uracil derivatives t with olefins, such as methyl acrylate, acrylonitrile, methyl vinyl ketone, and styrene, using one equivalent of palladium acetate leads to the corresponding 5-(1-alkenyl)uracil derivatives 2.

  使用一当量的醋酸钯，尿嘧啶衍生物t与丙烯酸甲酯、丙烯腈、乙烯基甲酮和苯乙烯等烯烃进行氧化偶联反应，可得到相应的5-(1-烯基)尿嘧啶衍生物2。
• METHOD OF DETECTING TARGET NUCLEIC ACID
  申请人：Toray Industries, Inc.

  公开号：US20150240296A1

  公开（公告）日：2015-08-27

  A method of detecting a target nucleic acid by sandwich hybridization using a detection probe that hybridizes with the target nucleic acid, and a capture probe immobilized on a support wherein at least one nucleic acid base in the nucleic acid molecule(s) of the detection probe and/or capture probe with a photoreactive group includes irradiating, with light, a complex formed by hybridization between the target nucleic acid and the detection probe and/or capture probe to allow formation of a covalent bond(s) between the photoreactive group(s) and a nucleic acid base(s) in the target nucleic acid.

  一种通过夹心杂交检测目标核酸的方法，使用与目标核酸杂交的检测探针和固定在支撑物上的捕获探针，其中检测探针和/或捕获探针的核酸分子中至少有一个含有光反应基团的核酸碱基，包括照射形成的复合物，即目标核酸和检测探针和/或捕获探针之间的杂交物，以允许光反应基团和目标核酸中的核酸碱基之间形成共价键。
• METHOD FOR DETECTING TARGET NUCLEIC ACID
  申请人：Toray Industries, Inc.

  公开号：EP2891721A1

  公开（公告）日：2015-07-08

  A method for detecting a target nucleic acid, which enables highly sensitive detection of the target nucleic acid without lowering the detection sensitivity (S/N ratio) even by use of a reduced amount of a detection probe, is disclosed. The method for detecting a target nucleic acid is based on sandwich hybridization using a detection probe that hybridizes with the target nucleic acid, and a capture probe immobilized on a support. In this method, at least one nucleic acid base in the nucleic acid molecule(s) of the detection probe and/or capture probe is substituted with a photoreactive group. The method comprises the step of irradiating, with light, a complex formed by hybridization between the target nucleic acid and the detection probe and/or capture probe to allow formation of a covalent bond(s) between the photoreactive group(s) and a nucleic acid base(s) in the target nucleic acid.

  本发明公开了一种检测目标核酸的方法，即使使用较少量的检测探针，也能对目标核酸进行高灵敏度检测，而不会降低检测灵敏度（信噪比）。这种检测目标核酸的方法基于三明治杂交法，使用与目标核酸杂交的检测探针和固定在支持物上的捕获探针。在该方法中，检测探针和/或捕获探针的核酸分子中至少有一个核酸碱基被光活性基团取代。该方法包括以下步骤：用光照射目标核酸与检测探针和/或捕获探针杂交形成的复合物，使光活性基团与目标核酸中的核酸碱基形成共价键。
• Singh, Harjit; Dolly; Chimni, Swapandeep Singh, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1996, vol. 35, # 11, p. 1123 - 1124
  作者：Singh, Harjit、Dolly、Chimni, Swapandeep Singh、Singh, Palwinder、Kumar, Subodh

  DOI：——

  日期：——
• HIROTA, KOSAKU;KITADE, YUKIO;ISOBE, YOSHIAKI;MAKI, YOSHIFUMI, HETEROCYCLES, 26,(1987) N 2, 355-358
  作者：HIROTA, KOSAKU、KITADE, YUKIO、ISOBE, YOSHIAKI、MAKI, YOSHIFUMI

  DOI：——

  日期：——