N-[(2-benzylthio)phenyl]salicylaldimine | 1446517-48-1

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: N-[(2-benzylthio)phenyl]salicylaldimine
• CAS: 1446517-48-1
• 化学式: C₂₀H₁₇NOS
• 分子量: 319.427
• InChiKey: QCGVSDXVDIBUFX-KGENOOAVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.44
• 重原子数：
  23.0
• 可旋转键数：
  5.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  32.59
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  nickel(II) nitrate hexahydrate 、 N-[(2-benzylthio)phenyl]salicylaldimine 在 sodium hydroxide 作用下， 以 甲醇 为溶剂， 反应 0.67h， 以62.1%的产率得到[Ni(N-[(2-benzylthio)phenyl]salicylaldimine(-1H))₂]·H₂O
  参考文献：
  名称：

  Synthesis, characterization, crystal structure and bioactivities of a new potential tridentate (ONS) Schiff base ligand N-[2-(benzylthio) phenyl] salicylaldimine and its Ni(II), Cu(II) and Co(II) complexes

  摘要：

  A series of new bichelated complexes of the formula [M(L)(2)]center dot H2O were synthesized from the reaction of N-[(2-benzylthio)-phenyl] salicylaldimine (HL), 1, a new tridentate (O, N, S donor) potential Schiff base with metal salts in methanol medium. These compounds were characterized by elemental analyses, FT-IR, UV-Visible and magnetic susceptibility studies. The crystal structures of the ligand I as well as two nickel(II) complexes [Ni(L)(2)]center dot H2O, 2 and 3, were determined by X-ray diffraction studies. The nickel atom is coordinated to two oxygen atoms, two nitrogen atoms and two sulfur atoms in bichelated fashion of the ligand, 1 indicating that the metal atom is in a slightly distorted octahedral environment. The bioactivity studies showed that the ligand and the complexes exhibit considerable antibacterial and antifungal activities against Bacillus subtilis (Gram +ve), Klebsiella pneumonia (Gram -ve) and Candida albicans. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2013.04.062
• 作为产物：
  描述：

  水杨醛 、 2-氨基苯基苯甲基硫代醚 以 乙醇 为溶剂， 反应 0.17h， 以82.9%的产率得到N-[(2-benzylthio)phenyl]salicylaldimine
  参考文献：
  名称：

  Synthesis, characterization, crystal structure and bioactivities of a new potential tridentate (ONS) Schiff base ligand N-[2-(benzylthio) phenyl] salicylaldimine and its Ni(II), Cu(II) and Co(II) complexes

  摘要：

  A series of new bichelated complexes of the formula [M(L)(2)]center dot H2O were synthesized from the reaction of N-[(2-benzylthio)-phenyl] salicylaldimine (HL), 1, a new tridentate (O, N, S donor) potential Schiff base with metal salts in methanol medium. These compounds were characterized by elemental analyses, FT-IR, UV-Visible and magnetic susceptibility studies. The crystal structures of the ligand I as well as two nickel(II) complexes [Ni(L)(2)]center dot H2O, 2 and 3, were determined by X-ray diffraction studies. The nickel atom is coordinated to two oxygen atoms, two nitrogen atoms and two sulfur atoms in bichelated fashion of the ligand, 1 indicating that the metal atom is in a slightly distorted octahedral environment. The bioactivity studies showed that the ligand and the complexes exhibit considerable antibacterial and antifungal activities against Bacillus subtilis (Gram +ve), Klebsiella pneumonia (Gram -ve) and Candida albicans. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2013.04.062