6-tert-butyl 1-ethyl (4S,5S,E)-4-(benzylthio)-5-hydroxyhex-2-enedioate | 1536481-23-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 6-tert-butyl 1-ethyl (4S,5S,E)-4-(benzylthio)-5-hydroxyhex-2-enedioate
• 英文别名: 6-O-tert-butyl 1-O-ethyl (E,4S,5S)-4-benzylsulfanyl-5-hydroxyhex-2-enedioate
• CAS: 1536481-23-8
• 化学式: C₁₉H₂₆O₅S
• 分子量: 366.478
• InChiKey: DECLHOPUSFVOKR-ZEERGYAVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  25
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  98.1
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  tert-butyl glyoxylate 、 2-(苯甲基巯基)乙醛 、 乙氧甲酰基亚甲基三苯基膦 在 N-(4,5-dihydro-3H-4-aza-cyclohepta[2,1-a;3,4-a']dinaphthalen-2-yl)-C,C,C-trifluoro-methanesulfonamide 作用下， 以 N-甲基吡咯烷酮 、 氯仿 为溶剂， 反应 14.0h， 以94%的产率得到
  参考文献：
  名称：

  Amine-Catalyzed Asymmetric Cross-Aldol Reactions Using Heterofunctionalized Acetaldehydes as Nucleophiles

  摘要：

  Various heterofunctionalized acetaldehydes were successfully employed in an amine-catalyzed asymmetric cross-aldol reaction, affording a variety of synthetically useful 1,2-difunctionalized compounds such as 1,2-diols and 1,2-aminoalcohols. With this method, both syn- and anti-1,2-difunctionalized compounds were obtained from the same set of reactants by using the appropriate amine catalyst.

  DOI：

  10.1021/ol4036837

文献信息

• Amine-Catalyzed Asymmetric Cross-Aldol Reactions Using Heterofunctionalized Acetaldehydes as Nucleophiles
  作者：Taichi Kano、Ryu Sakamoto、Keiji Maruoka

  DOI：10.1021/ol4036837

  日期：2014.2.7

  Various heterofunctionalized acetaldehydes were successfully employed in an amine-catalyzed asymmetric cross-aldol reaction, affording a variety of synthetically useful 1,2-difunctionalized compounds such as 1,2-diols and 1,2-aminoalcohols. With this method, both syn- and anti-1,2-difunctionalized compounds were obtained from the same set of reactants by using the appropriate amine catalyst.