N-methyl-4-(N,N-dimethylamino)benzylidene amine N-oxide | 16089-69-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-methyl-4-(N,N-dimethylamino)benzylidene amine N-oxide
• 英文别名: 1-[4-(dimethylamino)phenyl]-N-methylmethanimine oxide
• CAS: 16089-69-3；33184-68-8；203731-12-8
• 化学式: C₁₀H₁₄N₂O
• 分子量: 178.234
• InChiKey: ABKOTZUEXDIEIB-XYOKQWHBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  32
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-methyl-4-(N,N-dimethylamino)benzylidene amine N-oxide 、 甲胺 在 lead dioxide 作用下， 以 氯仿 为溶剂， 生成 4-(Dimethylamino)-N¹,N²-dimethylbenzamidinyl-N¹-oxid
  参考文献：
  名称：

  Aurich, Hans Guenter; Duggal, Suresh K.; Hoehlein, Peter, Chemische Berichte, 1981, vol. 114, # 7, p. 2440 - 2449

  摘要：

  DOI：
• 作为产物：
  描述：

  N-(4-dimethylamino-benzyl)-N-methyl-hydroxylamine 在 mercury(II) oxide 作用下， 以 氘代氯仿 为溶剂， 反应 2.0h， 生成 N-methyl,α-(4-dimethylamino)phenyl nitrone 、 N-methyl-4-(N,N-dimethylamino)benzylidene amine N-oxide
  参考文献：
  名称：

  Hassan, Azfar; Wazeer, Mohammed I. M.; Ali, Sk. Asrof, Journal of the Chemical Society. Perkin Transactions 2 (2001), 1998, # 2, p. 393 - 399

  摘要：

  DOI：

文献信息

• α,β-Unsaturated Fischer Carbene Complexes vs. 1,3-Dipoles: Reactions with Nitrones and Nitrilimines
  作者：José Barluenga、Félix Fernández-Marí、Rosario González、Enrique Aguilar、Gustavo A. Revelli、Argimiro L. Viado、Francisco J. Fañanás、Bernardo Olano

  DOI：10.1002/(sici)1099-0690(200005)2000:9<1773::aid-ejoc1773>3.0.co;2-e

  日期：2000.5

  The reaction of tert-butylalkynyl chromium Fischer carbene complex 1 with nitrones 2 affords β-enamino-ketoaldehydes 4 by the light-promoted rearrangement of the corresponding [3+2] cycloadduct carbene complexes 3. On the other hand, [3+2] cycloaddition of chiral nonracemic Fischer alkenyl carbene complexes 19 with nitrilimines 10 yields enantiomerically pure Δ2-pyrazolines with high regio- and diastereoselectivity

  叔丁基炔基铬 Fischer 卡宾配合物 1 与硝酮 2 的反应通过相应的 [3+2] 环加合物卡宾配合物 3 的光促进重排得到 β-烯氨基-酮醛 4。另一方面，[3+2]手性非外消旋 Fischer 烯基卡宾配合物 19 与腈亚胺 10 的环加成产生具有高区域选择性和非对映选择性的对映异构纯 Δ2-吡唑啉。
• Synthesis and mass spectral study of new phenylsulfonyl substituted isoxazolidines
  作者：Yaşar Dürüst、Cevher Altuğ、Jari Sinkkonen、Olli Martiskainen、Kalevi Pihlaja

  DOI：10.1002/jhet.5570430519

  日期：2006.9

  Ten 2,3-disubstituted 4-phenylsulfonyl isoxazolidines (3a-j) were prepared by 1,3-dipolar cycloaddition reaction of substituted nitrones (1a-j) with phenyl vinyl sulfone (2). The reaction products were identified by means of IR, NMR, and MS data. In addition, the factors influencing on the electron ionization induced mass spectral fragmentation of the title products are discussed in detail.

  通过取代的硝酮（1a-j）与苯基乙烯基砜（2）的1，3-偶极环加成反应制备了十个2，3-二取代的4-苯基磺酰基异恶唑烷（3a-j）。通过IR，NMR和MS数据鉴定反应产物。此外，还详细讨论了影响电子离解引起标题产物质谱碎裂的因素。
• Stereoselective synthesis and biological activity of novel spiro-oxazinanone-C-glycosides
  作者：Xiaoliu Li、Rui Wang、Yanpo Wang、Hua Chen、Zhiwei Li、Cuilan Ba、Jinchao Zhang

  DOI：10.1016/j.tet.2008.08.002

  日期：2008.10

  The stereoselective synthesis of novel spiro-oxazinanone nucleosides 9 and 10 has been achieved by microwave assisted 1,3-dipolar cycloaddition of exo-glucal (1) and nitrones (2), and followed by reduction, stereospecific recyclization, and catalytic deprotection. The structures of the spironucleosides were determined according to the H-1 NMR, C-13 NMR, 2D NMR, MS, and X-ray analyses, and the biological activities of the title compounds against glycosidases (alpha-amylase, alpha-glucosidase, and beta-glucosidase) and cytotoxicity were also evaluated. (C) 2008 Elsevier Ltd. All rights reserved.
• STAMM H.; STEUDLE H., TETRAHEDRON, 1979, 35, NO 5, 647-650
  作者：STAMM H.、 STEUDLE H.

  DOI：——

  日期：——
• HWU, JIH RU;ROBL, JEFFREY A.;WANG, NAELONG;ANDERSON, DENISE A.;KU, JAMES;+, J. CHEM. SOC. PERKIN TRANS. PT 1,(1989) N0, C. 1823-1831
  作者：HWU, JIH RU、ROBL, JEFFREY A.、WANG, NAELONG、ANDERSON, DENISE A.、KU, JAMES、+

  DOI：——

  日期：——