5-bromo-6-[2-methoxy-4-(trifluoromethyl)phenyl]-N-methyl-3-(1-propylbutoxy)pyrazin-2-amine | 666253-93-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 5-bromo-6-[2-methoxy-4-(trifluoromethyl)phenyl]-N-methyl-3-(1-propylbutoxy)pyrazin-2-amine
• 英文别名: 5-bromo-3-heptan-4-yloxy-6-[2-methoxy-4-(trifluoromethyl)phenyl]-N-methylpyrazin-2-amine
• CAS: 666253-93-6
• 化学式: C₂₀H₂₅BrF₃N₃O₂
• 分子量: 476.337
• InChiKey: HTZFYMSDBVJCNY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  29
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  56.3
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• [EN] 5-SUBSTITUTED-2-ARYLPYRAZINES AS MODULATORS OF CRF RECEPTORS<br/>[FR] 2-ARYLPYRAZINES SUBSTITUEES EN 5 COMME MODULATEURS SUR LES RECEPTEURS CRF
  申请人：NEUROGEN CORP

  公开号：WO2004018437A1

  公开（公告）日：2004-03-04

  Novel 5-substituted-2-arylpyrazine compounds are provided. Such compounds can act as selective modulators of CRF receptors. The 5-substituted-2-arylpyrazine compounds provided herein are useful in the treatment of a number of CNS and peripheral disorders, particularly stress, anxiety, depression, cardiovascular disorders, and eating disorders. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also provided. Compounds provided are also useful as probes for the localization of CRF receptors and as standards in assays for CRF receptor binding. Methods of using the compounds in receptor localization studies are given.

  提供了一种新型的5-取代-2-芳基吡嗪化合物。这些化合物可以作为CRF受体的选择性调节剂。本文提供的5-取代-2-芳基吡嗪化合物在治疗多种中枢神经系统和外周疾病方面具有用途，特别是压力、焦虑、抑郁、心血管疾病和进食障碍。还提供了治疗这些疾病的方法以及包装的药物组合物。提供的化合物还可用作CRF受体的定位探针和CRF受体结合测定中的标准。给出了在受体定位研究中使用这些化合物的方法。
• 5-Substituted-2-arylpyrazines
  申请人：Neurogen Corporation

  公开号：US20040106620A1

  公开（公告）日：2004-06-03

  Novel 5-substituted-2-arylpyrazine compounds are provided. Such compounds can act as selective modulators of CRF receptors. The 5-substituted-2-arylpyrazine compounds provided herein are useful in the treatment of a number of CNS and periphereal disorders, particularly stress, anxiety, depression, cardiovascular disorders, and eating disorders. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also provided. Compounds provided are also useful as probes for the localization of CRF receptors and as standards in assays for CRF receptor binding. Methods of using the compounds in receptor localization studies are given.

  本文提供了一种新型的5-取代-2-芳基吡嗪化合物。这些化合物可以作为选择性CRF受体调节剂。本文提供的5-取代-2-芳基吡嗪化合物在治疗多种中枢神经系统和外周疾病方面具有用途，尤其是在应对压力、焦虑、抑郁、心血管疾病和进食障碍方面。此外，还提供了治疗这些疾病的方法和包装的药物组合物。这些化合物还可用作CRF受体定位的探针和CRF受体结合测定的标准。本文还提供了使用这些化合物进行受体定位研究的方法。
• 5-SUBSTITUTED-2-ARYLPYRAZINES AS MODULATORS OF CRF RECEPTORS
  申请人：NEUROGEN CORPORATION

  公开号：EP1554258A1

  公开（公告）日：2005-07-20
• US7179807B2
  申请人：——

  公开号：US7179807B2

  公开（公告）日：2007-02-20