4-[(5-溴噻吩-2-基)甲基]吗啉 | 364793-76-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 4-[(5-溴噻吩-2-基)甲基]吗啉
• 英文名称: 4-[(5-bromo-2-thienyl) methyl]-morpholine
• 英文别名: 4-[(5-Bromothiophen-2-yl)methyl]morpholine
• CAS: 364793-76-0
• 化学式: C₉H₁₂BrNOS
• 分子量: 262.17
• InChiKey: XTTAOCHKCUOJFW-UHFFFAOYSA-N

物化性质

• 沸点：
  308.9±37.0 °C(Predicted)
• 密度：
  1.519±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  40.7
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2934999090

反应信息

• 作为反应物：
  描述：

  7-bromo-4-[(2,4-dichloro-5-methoxyphenyl)amino]-3-quinolinecarbonitrile 、 4-[(5-溴噻吩-2-基)甲基]吗啉 在 四(三苯基膦)钯 、 碳酸氢钠 作用下， 以 乙二醇二甲醚 为溶剂， 生成 4-(2,4-Dichloro-5-methoxyanilino)-7-[5-(4-morpholinylmethyl)-thien-2-yl]-3-quinolinecarbonitrile
  参考文献：
  名称：

  Inhibition of Src kinase activity by 4-anilino-7-thienyl-3-quinolinecarbonitriles

  摘要：

  Based on a screening lead from a yeast-based assay to identify Src family kinase inhibitors, a series of 4-anilino-7-thienyl-3-quinolinecarbonitriles was prepared. When the thiophene ring was substituted with a water-solubilizing group in a 2,5-, 3,5- or 2,4-pattern, potent inhibition of Src kinase activity was observed. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00302-5
• 作为产物：
  描述：

  吗啉 、 5-溴噻吩-2-甲醛 在 sodium cyanoborohydride 、 溶剂黄146 作用下， 以 乙醇 为溶剂， 生成 4-[(5-溴噻吩-2-基)甲基]吗啉
  参考文献：
  名称：

  Inhibition of Src kinase activity by 4-anilino-7-thienyl-3-quinolinecarbonitriles

  摘要：

  Based on a screening lead from a yeast-based assay to identify Src family kinase inhibitors, a series of 4-anilino-7-thienyl-3-quinolinecarbonitriles was prepared. When the thiophene ring was substituted with a water-solubilizing group in a 2,5-, 3,5- or 2,4-pattern, potent inhibition of Src kinase activity was observed. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00302-5

文献信息

• 3-cyanoquinolines, 3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors
  申请人：American Home Products Corporation

  公开号：US20020026052A1

  公开（公告）日：2002-02-28

  This invention provides compounds of Formula (I), having the structure 1 where T, Z, X, A, R 1 , R 2a , R 2b , R 2c , R 3 , R 4 , and n are defined herein, or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the treatment of osteoporosis and polycystic kidney disease.

  这项发明提供了具有结构的化合物（I）的公式， 其中T、Z、X、A、R 1 、R 2a 、R 2b 、R 2c 、R 3 、R 4 和n在此处定义，或其药学上可接受的盐，这些化合物可用作抗肿瘤药物，并用于骨质疏松症和多囊肾病的治疗。
• [EN] 3-CYANOQUINOLINES,3-CYANO-1,6-NAPHTHYRIDINES, AND 3-CYANO-1,7-NAPHTHYRIDINES AS PROTEIN KINASE INHIBITORS<br/>[FR] 3-CYANOQUINOLINES,3-CYANO-1,6-NAPHTHYRIDINES ET 3-CYANO-1,7-NAPHTHYRIDINES UTILISEES COMME INHIBITEURS DE PROTEINEKINASE
  申请人：AMERICAN HOME PROD

  公开号：WO2001072711A1

  公开（公告）日：2001-10-04

  Compounds of Formula (I), having the structure or a pharmaceutically salt thereof are useful as antineoplastic agents and in the treatment of osteoporosis and polycystic kidney disease.

  具有结构式（I）或其药物盐的化合物在抗肿瘤药物和治疗骨质疏松症和多囊肾病方面是有用的。
• Novel compounds
  申请人：——

  公开号：US20040242573A1

  公开（公告）日：2004-12-02

  The invention relates to thiophene carboxanmides of formula (I). wherein A, R 1 , R 2 , R 3 , n and X are as defined in the specification, processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy. 1

  本发明涉及公式（I）的噻吩羧酰胺，其中A，R1，R2，R3，n和X如规范中定义的，以及用于其制备的工艺和中间体，含有它们的制药组合物以及它们在治疗中的使用。
• Thiophene carboxamide compounds as inhibitors of enzyme IKK-2
  申请人：AstraZeneca AB

  公开号：US07125896B2

  公开（公告）日：2006-10-24

  The invention relates to thiophene carboxanmides of formula (I), wherein A, R1, R2, R3, n and X are as defined in the specification, processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy.

  本发明涉及公式（I）的噻吩羧酰胺，其中A，R1，R2，R3，n和X如规范中所定义，用于制备它们的过程和中间体，包含它们的制药组合物以及它们在治疗中的使用。
• Novel Compounds
  申请人：Faull Alan

  公开号：US20110152234A1

  公开（公告）日：2011-06-23

  The invention relates to thiophene carboxamides of formula (I), wherein A, R 1 , R 2 , R 3 , n and X are as defined in the specification, processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy.

  该发明涉及式(I)的噻吩羧酰胺，其中A、R1、R2、R3、n和X如规范中所定义，以及用于其制备的过程和中间体，含有它们的制药组合物以及它们在治疗中的使用。