N-benzylidene-propylamine | 6852-55-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-benzylidene-propylamine
• 英文别名: 1-phenyl-N-propylmethanimine；N-benzylidenepropylamine；N-benzylidene-n-propylamine
• CAS: 6852-55-7；27845-48-3
• 化学式: C₁₀H₁₃N
• 分子量: 147.22
• InChiKey: DFROALYLRQTARX-LUAWRHEFSA-N

物化性质

• 沸点：
  225.1±9.0 °C(Predicted)
• 密度：
  0.87±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.52
• 重原子数：
  11.0
• 可旋转键数：
  3.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  12.36
• 氢给体数：
  0.0
• 氢受体数：
  1.0

安全信息

• 海关编码：
  2925290090

反应信息

• 作为反应物：
  描述：

  N-benzylidene-propylamine 在 potassium carbonate 作用下， 以 乙腈 为溶剂， 反应 24.5h， 生成 (5Z)-5-benzylidene-2-ethylsulfanyl-3-methyl-3,5-dihydro-4H-imidazol-4-one
  参考文献：
  名称：

  Synthesis of N,N′-bis(5-arylidene-4-oxo-3,5-dihydro-4H-imidazol-2-yl)diamines bearing various linkers and biological evaluation as potential inhibitors of kinases

  摘要：

  The synthesis in 4 steps of new N,N'-bis(5-arylidene-4-oxo-3,5-dihydro-4H-imidazol-2-yl)diamines issued from various symmetric primary diamines as linkers was reported. The key step of our strategy has been the sulphur/nitrogen displacement of (5Z)-5-arylidene-2-ethylsulfanyl-3,5-dihydro-4H-imidazol-4-ones 6 with respectively ethylenediamine 7a, piperazine 7b and N,N'-bis(3-aminopropyl)piperazine 7c using solvent-free reaction conditions under microwave irradiation with retention of configuration. These compounds were tested for their kinase inhibitory potencies toward four kinases (GSK-3 alpha/beta, DYRK1A, CLK1 and CLK3). Crown Copyright (C) 2012 Published by Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2012.08.044
• 作为产物：
  描述：

  正丙胺 、 苯甲醛 以 neat (no solvent) 为溶剂， 反应 0.5h， 以92%的产率得到N-benzylidene-propylamine
  参考文献：
  名称：

  Synthesis of N,N′-bis(5-arylidene-4-oxo-3,5-dihydro-4H-imidazol-2-yl)diamines bearing various linkers and biological evaluation as potential inhibitors of kinases

  摘要：

  The synthesis in 4 steps of new N,N'-bis(5-arylidene-4-oxo-3,5-dihydro-4H-imidazol-2-yl)diamines issued from various symmetric primary diamines as linkers was reported. The key step of our strategy has been the sulphur/nitrogen displacement of (5Z)-5-arylidene-2-ethylsulfanyl-3,5-dihydro-4H-imidazol-4-ones 6 with respectively ethylenediamine 7a, piperazine 7b and N,N'-bis(3-aminopropyl)piperazine 7c using solvent-free reaction conditions under microwave irradiation with retention of configuration. These compounds were tested for their kinase inhibitory potencies toward four kinases (GSK-3 alpha/beta, DYRK1A, CLK1 and CLK3). Crown Copyright (C) 2012 Published by Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2012.08.044

文献信息

• Process for controlling the catalytic co-oligomerization of 1,3-dienes
  申请人：Studiengesellschaft Kohle mbH.

  公开号：US04163024A1

  公开（公告）日：1979-07-31

  A process has been developed for controlling the catalytic co-oligmoerization of 1,3-dienes with Schiff's bases which comprises condensing a 1,3-diene of the formula ##STR1## wherein R.sup.4 and R.sup.5, independently of one another, represent hydrogen or an alkyl group having 1 to 4 carbon atoms with a Schiff base of the formula ##STR2## wherein each of R.sup.1, R.sup.2 and R.sup.3 represents hydrogen alkyl, cycloalkyl, aralkyl, aryl or dimethylamino groups which, in addition, optionally contain functional groups of the group consisting of ethers esters, C.dbd.N double bonds and which can be closed to form a ring, in the presence of a nickel (O)-containing catalyst, and optionally in the presence of an X--H compound with a molar ratio of Ni: X H of from 1:0 to 1:10.

  已经开发出一种用于控制1,3-二烯与席夫碱的催化共聚合的过程，包括将式为##STR1##的1,3-二烯与式为##STR2##的席夫碱缩合，其中R.sup.4和R.sup.5分别独立地表示氢或具有1至4个碳原子的烷基基团；每个R.sup.1、R.sup.2和R.sup.3表示氢、烷基、环烷基、芳基烷基、芳基或二甲基氨基基团，此外，还可以选择地包含醚、酯、C.dbd.N双键的官能团，并且可以闭合形成环，在存在含镍（O）的催化剂和可选的X-H化合物的情况下进行，其中Ni：X H的摩尔比为1:0至1:10。
• TITANIUM CATALYST, ORGANOTITANIUM REACTION REAGENT, PROCESSES FOR PRODUCING THESE, AND METHOD OF REACTION USING THESE
  申请人：NISSAN CHEMICAL INDUSTRIES, LIMITED

  公开号：EP0820809A1

  公开（公告）日：1998-01-28

  A titanium catalyst for reaction between a carbon-carbon unsaturated bond and a compound having an electrophilic functional group or an electrophilic reagent, said titanium catalyst being composed of a titanium compound represented by the formula (1) below         TiX1X2X3X4     (1) (where X1, X2, X3, and X4 denote independently a halogen atom, C1-20 alkoxyl group, aralkyloxy group, aryloxy group, or -NRxRy group (where Rx and Ry denote independently a C1-20 alkyl group or aralkyl group), and any two of X1, X2, X3, and X4 may form a ring.) and a Grignard reagent represented by the formula (2) below in a molar amount 1.5-2.5 times as much as the titanium compound.         R1MgX5     (2) (where R1 denotes a C2-10 alkyl group having a hydrogen atom at the β position and X5 denotes a halogen atom.) The titanium catalyst of the present invention activates the carbon-carbon unsaturated bond, which has a comparatively low reactivity, thereby catalyzing the reaction with an electrophilic functional group. It is inexpensive and industrially advantageous. When applied to reaction between a carbon-carbon unsaturated bond and an electrophilic functional group, it yields industrially a variety of adducts of a compound having a carbon-carbon unsaturated bond and a compound having an electrophilic functional group, and it also yields a variety of intramolecular adducts of a compound having a carbon-carbon unsaturated bond and an electrophilic functional group in the same molecule.

  一种钛催化剂，用于碳-碳不饱和键与具有亲电官能团或亲电试剂的化合物之间的反应，所述钛催化剂由下式（1）表示的钛化合物组成 TiX1X2X3X4 (1) (其中 X1、X2、X3 和 X4 独立地表示卤素原子、C1-20 烷氧基、芳氧基、芳烷氧基或 -NRxRy 基团（其中 Rx 和 Ry 独立地表示 C1-20 烷基或芳烷基），且 X1、X2、X3 和 X4 中的任意两个可形成一个环）和下式（2）表示的格氏试剂，其摩尔量为钛化合物的 1.5-2.5 倍。 R1MgX5 (2) (其中 R1 表示在 β 位有一个氢原子的 C2-10 烷基，X5 表示卤素原子)。 本发明的钛催化剂可激活反应活性相对较低的碳-碳不饱和键，从而催化亲电官能团反应。这种催化剂价格低廉，具有工业优势。当应用于碳-碳不饱和键与亲电官能团之间的反应时，它可在工业上生成具有碳-碳不饱和键的化合物与具有亲电官能团的化合物的各种加合物，还可在同一分子中生成具有碳-碳不饱和键的化合物与具有亲电官能团的化合物的各种分子内加合物。
• Preparation process of aminoacetamide derivative
  申请人：Eisai Co., Ltd.

  公开号：EP0714885B1

  公开（公告）日：1999-09-01
• Sato, Masayuki; Ogasawara, Hiromichi; Yoshizumi, Eriko, Heterocycles, 1982, vol. 17, p. 297 - 300
  作者：Sato, Masayuki、Ogasawara, Hiromichi、Yoshizumi, Eriko、Kato, Tetsuzo

  DOI：——

  日期：——
• Synthesis of trimethylsilyl-substituted .alpha.-allenic and .beta.-acetylenic amines from imines and propargylic and allenic organoboranes
  作者：Sham S. Nikam、Kung K. Wang

  DOI：10.1021/jo00212a039

  日期：1985.6