N-Acetyl-S-succinylhomocystein | 57753-01-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-Acetyl-S-succinylhomocystein
• 英文别名: 2-Acetamido-4-(3-carboxypropanoylsulfanyl)butanoic acid
• CAS: 57753-01-2
• 化学式: C₁₀H₁₅NO₆S
• 分子量: 277.298
• InChiKey: IWPOJLHIQNBCOY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  18
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  146
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• Cell-permeable succinate compounds
  申请人：NEUROVIVE PHARMACEUTICAL AB

  公开号：US11147789B2

  公开（公告）日：2021-10-19

  The present invention provides novel cell-permeable succinates and cell permeable precursors of succinateaimed at increasing ATP-production in mitochondria. The main part of ATP produced and utilized in the eukaryotic cell originates from mitochondrial oxidative phosphorylation, a process to which high-energy electrons are provided by the Kreb's cycle. Not all Kreb's cycle intermediates are readily permeable to the cellular membrane, one of them being succinate. The provision of the novel cell permeable succinates is envisaged to allow passage over the cellular membrane and thus the cell permeable succinates can be used to enhance mitochondrial ATP-output.

  本发明提供了新型细胞渗透性琥珀酸盐和细胞渗透性琥珀酸盐前体，旨在增加线粒体中的 ATP 生成。真核细胞中产生和利用的 ATP 主要来自线粒体氧化磷酸化，这一过程由克雷伯循环提供高能电子。并非所有的克雷伯循环中间产物都能轻易渗透到细胞膜中，琥珀酸就是其中之一。设想提供新型细胞渗透性琥珀酸盐可使其通过细胞膜，因此细胞渗透性琥珀酸盐可用于提高线粒体 ATP 的输出。
• Novel Cell-Permeable Succinate Compounds
  申请人：NEUROVIVE PHARMACEUTICAL AB

  公开号：US20170105961A1

  公开（公告）日：2017-04-20

  The present invention provides novel cell-permeable succinates and cell permeable precursors of succinateaimed at increasing ATP-production in mitochondria. The main part of ATP produced and utilized in the eukaryotic cell originates from mitochondrial oxidative phosphorylation, a process to which high-energy electrons are provided by the Kreb's cycle. Not all Kreb's cycle intermediates are readily permeable to the cellular membrane, one of them being succinate. The provision of the novel cell permeable succinates is envisaged to allow passage over the cellular membrane and thus the cell permeable succinates can be used to enhance mitochondrial ATP-output.
• NOVEL CELL-PERMEABLE SUCCINATE COMPOUNDS
  申请人：ABLIVA AB

  公开号：US20210401792A1

  公开（公告）日：2021-12-30

  The present invention provides novel cell-permeable succinates and cell permeable precursors of succinate aimed at increasing ATP-production in mitochondria. The main part of ATP produced and utilized in the eukaryotic cell originates from mitochondrial oxidative phosphorylation, a process to which high-energy electrons are provided by the Kreb's cycle. Not all Kreb's cycle intermediates are readily permeable to the cellular membrane, one of them being succinate. The provision of the novel cell permeable succinates is envisaged to allow passage over the cellular membrane and thus the cell permeable succinates can be used to enhance mitochondrial ATP-output.