乙酸酐-T3 | 67341-27-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 乙酸酐-T3
• 英文名称: all-tritium acetic anhydride
• 英文别名: <3H>-Essigsaeureanhydrid；[2,2,2,2',2',2'-³H]acetic acid anhydride；(2,2,2-tritritioacetyl) 2,2,2-tritritioacetate
• CAS: 67341-27-9
• 化学式: C₄H₆O₃
• 分子量: 114.042
• InChiKey: WFDIJRYMOXRFFG-VQBNBCTGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  7
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  乙酸酐-T3 、 taxumairol F 在 4-二甲氨基吡啶 作用下， 以 二氯甲烷 为溶剂， 以90%的产率得到
  参考文献：
  名称：

  紫杉醇氧杂环丁烷环 D 前体的合成和体外评价

  摘要：

  以放射性标记的形式制备了一系列潜在的紫杉醇底物，以在体外探测环氧乙烷的形成步骤和随后的环扩展步骤，可能与抗癌剂紫杉醇的生物合成有关的氧杂环丁烷（环 D）。紫杉类测试底物均未在来自红豆杉的无细胞系统中进行转化，这表明这些替代物具有不适合目标酶识别或催化的替代模式，或者紫杉类环氧乙烷和氧杂环丁烷通过独立的生物合成途径产生。

  DOI：

  10.1016/j.tetlet.2010.02.033

文献信息

• Δ⁹-Tetrahydrocannabinol Immunochemical Studies:  Haptens, Monoclonal Antibodies, and a Convenient Synthesis of Radiolabeled Δ⁹-Tetrahydrocannabinol
  作者：Longwu Qi、Noboru Yamamoto、Michael M. Meijler、Laurence J. Altobell、George F. Koob、Peter Wirsching、Kim D. Janda

  DOI：10.1021/jm050442r

  日期：2005.11.1

  Immunopharmacotherapy as an approach to combat drugs of abuse has become an active area of investigation. Marijuana is the most commonly used illicit drug in the U.S. The main active chemical in marijuana is Delta(9)-tetrahydrocannabinol (Delta(9)-THC); hence, monoclonal antibodies with high affinity and specificity for Delta(9)-tetrahydrocannabinol could be valuable immunopharmacotherapeutic intervention and diagnostic tools. We have synthesized immunoconjugates that induce an effective immune response to Delta(9)-THC and describe a convenient synthesis of radiolabeled Delta(9)-THC. We demonstrate the value and use of this probe to select anti-Delta(9)-THC antibodies that bind Delta(9)-THC with good affinity. The synthetic route to radiolabeled Delta(9)-THC has enabled the correct assessment of the affinity of these antibodies to their ligand and may facilitate future binding studies between Delta(9)-THC and its analogues and the cannabinoid receptors.
• Total synthesis of the-potent proteasome inhibitor epoxomicin: a useful tool for understanding proteasome biology
  作者：Ny Sin、Kyung Bo Kim、Mikael Elofsson、Lihao Meng、Hak Auth、Benjamin H.B. Kwok、Craig M. Crews

  DOI：10.1016/s0960-894x(99)00376-5

  日期：1999.8

  Epoxomicin (1), a peptide alpha',beta'-epoxyketone isolated from the actinomycete strain No.Q996-17, possesses potent in vivo anti-tumor and anti-inflammatory activities. In this paper, we report the first syntheses of epoxomicin, [H-3]-epoxomicin, and a biotinylated epoxomicin analog as well as the absolute configuration of the epoxide stereocenter. The natural product and derivatives have permitted the first identification of the proteasome as the specific cellular target of epoxomicin. (C) 1999 Elsevier Science Ltd. All rights reserved.
• POMPER, MARTIN G.;PINNEY, KEVIN G.;CARLSON, KATHRYN E.;VAN, BROCKLIN HENR+, NUCL. MED. AND BIOL., 17,(1990) N, C. 309-319
  作者：POMPER, MARTIN G.、PINNEY, KEVIN G.、CARLSON, KATHRYN E.、VAN, BROCKLIN HENR+

  DOI：——

  日期：——
• CHAN, K. K.;PANG, K. S., J. LABELLED COMPOUNDS AND RADIOPHARM., 1982, 19, N 3, 321-329
  作者：CHAN, K. K.、PANG, K. S.

  DOI：——

  日期：——