5-amino-2-(4-hydroxyphenyl)-3H-chromeno[4,3,2-de][1,6]naphthyridine-4-carbonitrile | 1204405-78-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 5-amino-2-(4-hydroxyphenyl)-3H-chromeno[4,3,2-de][1,6]naphthyridine-4-carbonitrile
• CAS: 1204405-78-6
• 化学式: C₂₁H₁₂N₄O₂
• 分子量: 352.352
• InChiKey: OCFNXOANRREUKH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.23
• 重原子数：
  27.0
• 可旋转键数：
  1.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  105.05
• 氢给体数：
  2.0
• 氢受体数：
  6.0

反应信息

• 作为产物：
  描述：

  2'-羟基苯乙酮 、 对羟基苯甲醛 、 丙二腈 在 Fe₃O₄ 作用下， 以 水 为溶剂， 以81%的产率得到5-amino-2-(4-hydroxyphenyl)-3H-chromeno[4,3,2-de][1,6]naphthyridine-4-carbonitrile
  参考文献：
  名称：

  Microwave-assisted Fe3O4 nanoparticles catalyzed synthesis of chromeno[1,6]naphthyridines in aqueous media

  摘要：

  Fe3O4 nanocatalyst was prepared by co-precipitation method and characterized by XRD, FT-IR, TEM, VSM and BET analyses. The particles have an average size of 7 nm and possess highly open mesopores, moderate surface area, and uniform morphology with superparamagnetic behavior. Activity of catalyst was probed through the synthesis of chromeno[1,6]naphthyridines in water under microwave irradiation (MW) and it was about 7-fold higher as compared to conventional method. Nanocatalyst plays a dual role of catalyst as well as susceptor, and enhances the overall capacity to absorb MW. Fe3O4 NPs easily recovered by simple magnetic separation and recycled at least 5 times. (C) 2014 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.catcom.2014.12.015