Convenient Synthesis of Ethyl 4-Aryl-6-(trifluoromethyl)-2-oxo-2<i>H</i>-pyran-3-carboxylates and 4-Aryl-6-(trifluoromethyl)-2<i>H</i>-pyran-2-ones: Novel Highly Reactive CF<sub>3</sub>-Containing Building Blocks
作者:Boris I. Usachev、Dmitrii L. Obydennov、Gerd-Volker Röschenthaler、Vyacheslav Ya. Sosnovskikh
DOI:10.1021/ol800992z
日期:2008.7.3
An expedient synthesis of a series of 2-pyrones, bearing a CF3 group at the 6-position and aryl group at position 4, from readily available aryl-4,4,4-trifluorobutane-1,3-diones, PCl5, and sodium diethyl malonate is described.