4-methoxy-N-(1-(2-oxooxazolidin-3-yl)hex-2-enylidene)benzenesulfonamide | 1274906-31-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-methoxy-N-(1-(2-oxooxazolidin-3-yl)hex-2-enylidene)benzenesulfonamide
• CAS: 1274906-31-8
• 化学式: C₁₆H₂₀N₂O₅S
• 分子量: 352.411
• InChiKey: ZVPGROXAIOPASI-OJBURCBUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.59
• 重原子数：
  24.0
• 可旋转键数：
  6.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  85.27
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为产物：
  描述：

  对甲氧基苯磺酰氯 在 [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene]gold bis(trifluoromethanesulfonyl)imidate 、 三乙胺 作用下， 以 四氢呋喃 、 1,2-二氯乙烷 为溶剂， 生成 4-methoxy-N-(1-(2-oxooxazolidin-3-yl)hex-2-enylidene)benzenesulfonamide 、 4-methoxy-N-(1-(2-oxooxazolidin-3-yl)hex-2-enylidene)benzenesulfonamide
  参考文献：
  名称：

  Gold-Catalyzed Nitrene Transfer to Activated Alkynes: Formation of α,β-Unsaturated Amidines

  摘要：

  A gold-catalyzed intermolecular nitrene transfer to alkynes was developed for the first time, revealing a new mode of nitrene transfer and providing a novel access to versatile alpha-imino metal carbenes. Various mild nitrene-transfer reagents were examined, and iminopyridium ylides especially those based on 3,5-dichloropyridine proved be highly effective. With activated alkynes such as N-alkynyloxazolidinones as substrates, alpha,beta-unsaturated amidines were formed in mostly good yields.

  DOI：

  10.1021/ol2002607