diethyl 2,6-dihydroxy-4-(4-nitrophenyl)-2,6-bis(1,1,2,2-tetrafluoroethyl)tetrahydro-2H-pyran-3,5-dicarboxylate | 1235453-03-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: diethyl 2,6-dihydroxy-4-(4-nitrophenyl)-2,6-bis(1,1,2,2-tetrafluoroethyl)tetrahydro-2H-pyran-3,5-dicarboxylate
• 英文别名: Diethyl 2,6-dihydroxy-4-(4-nitrophenyl)-2,6-bis-(1,1,2,2-tetrafluoroethyl)tetrahydro-2h-pyran-3,5-dicarboxylate；diethyl 2,6-dihydroxy-4-(4-nitrophenyl)-2,6-bis(1,1,2,2-tetrafluoroethyl)oxane-3,5-dicarboxylate
• CAS: 1235453-03-8
• 化学式: C₂₁H₂₁F₈NO₉
• 分子量: 583.386
• InChiKey: BZXDXEWZDQMPDL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  39
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  148
• 氢给体数：
  2
• 氢受体数：
  17

反应信息

• 作为产物：
  描述：

  对硝基苯甲醛 、 ethyl 4,4,5,5-tetrafluoro-3-oxopentanoate 在 potassium carbonate 、 1-butyl-3-methylimidazolium Tetrafluoroborate 作用下， 反应 18.0h， 以75%的产率得到diethyl 2,6-dihydroxy-4-(4-nitrophenyl)-2,6-bis(1,1,2,2-tetrafluoroethyl)tetrahydro-2H-pyran-3,5-dicarboxylate
  参考文献：
  名称：

  Synthesis of 2,6-bis(fluoroalkyl)-2,6-dihydroxytetrahydro-2H-pyran-3,5-dicarboxylates from aldehydes and fluorinated β-oxo esters in the presence of ionic liquid-K2CO3 as catalytic system

  摘要：

  An efficient procedure has been developed for the synthesis of 4-substituted 2,6-bis(fluoroalkyl)-2,6-dihydroxytetrahydro-2H-pyran-3,5-dicarboxylates by reactions of aldehydes with fluorine-containing beta-oxo esters in heterogeneous catalytic system 1-butyl-3-methylimidazolium tetrafluoroborate [bmim][BF4]-K2CO3 activated by ultrasound. The system retains its catalytic activity for three reaction cycles.

  DOI：

  10.1134/s1070428010040020