4-[2-(6,7-二甲氧基-4-甲基-3-氧代-3,4-二氢-喹喔啉-2-基)-乙基]-[1,2,4]三唑烷-3,5-二酮 | 132788-54-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 中文名称: 4-[2-(6,7-二甲氧基-4-甲基-3-氧代-3,4-二氢-喹喔啉-2-基)-乙基]-[1,2,4]三唑烷-3,5-二酮
• 英文名称: 4-[2-(6,7-Dimethoxy-4-methyl-3-oxo-3,4-dihydro-quinoxalin-2-yl)-ethyl]-[1,2,4]triazolidine-3,5-dione
• 英文别名: 4-[2-(6,7-Dimethoxy-4-methyl-3-oxo-3,4-dihydro-quinoxalin-2-yl)-ethyl]-[1,2,4]triazolidine-3,5-dion；4-[2-(6,7-dimethoxy-4-methyl-3-oxoquinoxalin-2-yl)ethyl]-1,2,4-triazolidine-3,5-dione
• CAS: 132788-54-6
• 化学式: C₁₅H₁₇N₅O₅
• 分子量: 347.33
• InChiKey: FIFOBLAJVDEWFN-UHFFFAOYSA-N

物化性质

• 密度：
  1.53±0.1 g/cm3(Predicted)
• 溶解度：
  可溶于二甲基亚砜、甲醇

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  113
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  4-[2-(6,7-二甲氧基-4-甲基-3-氧代-3,4-二氢-喹喔啉-2-基)-乙基]-[1,2,4]三唑烷-3,5-二酮 在 碘苯二乙酸 作用下， 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Synthesis of highly fluorescent dienophiles for detecting conjugated dienes in biological fluid

  摘要：

  具有高荧光取代基的氟源二烯亲体，1,2,4-三氮唑-3,5-二酮衍生物1a、b被合成作为检测带有共轭二烯基的生物化合物的试剂。

  DOI：

  10.1039/c39900001416
• 作为产物：
  描述：

  1,2-二氨基-4,5-二甲氧基苯 在 二苯基膦叠氮化物 、 potassium carbonate 、 三乙胺 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 、 苯 为溶剂， 反应 7.5h， 生成 4-[2-(6,7-二甲氧基-4-甲基-3-氧代-3,4-二氢-喹喔啉-2-基)-乙基]-[1,2,4]三唑烷-3,5-二酮
  参考文献：
  名称：

  Synthesis of highly fluorescent dienophiles for detecting conjugated dienes in biological fluid

  摘要：

  具有高荧光取代基的氟源二烯亲体，1,2,4-三氮唑-3,5-二酮衍生物1a、b被合成作为检测带有共轭二烯基的生物化合物的试剂。

  DOI：

  10.1039/c39900001416

文献信息

• Separating and quantifying unbound target analytes from biological samples
  申请人：ARUP Laboratories, Inc

  公开号：US11071927B2

  公开（公告）日：2021-07-27

  A method of separating free target analyte from protein-bound target analyte is described. Such can include obtaining an aqueous sample containing a target analyte in a free form (free target analyte) and the target analyte in a protein-bound form (protein-bound target analyte), passing the aqueous sample through a size exclusion chromatography matrix with a molecular weight cut off sufficient to allow the free target analyte to permeate into pores of the size exclusion chromatography matrix and exclude the protein-bound target analyte, whereupon the free target analyte adheres to and is immobilized by the size exclusion chromatography matrix and the protein-bound target analyte does not adhere to by the size exclusion chromatography matrix, separating the free target analyte from the protein-bound analyte by removing the protein-bound target analyte from the size exclusion chromatography matrix, and eluting the free target analyte from the size exclusion chromatography matrix with an organic solvent.

  描述了一种分离游离目标分析物和蛋白结合目标分析物的方法。这种方法可以包括获得含有游离形式的目标分析物（游离目标分析物）和蛋白结合形式的目标分析物（蛋白结合目标分析物）的水样，将水样通过尺寸排阻层析基质，该基质的分子量截距足以使游离目标分析物渗透到尺寸排阻层析基质的孔隙中，并排除蛋白结合目标分析物、在此情况下，游离的目标分析物附着在尺寸排阻色谱基质上并被尺寸排阻色谱基质固定，而蛋白结合的目标分析物不附着在尺寸排阻色谱基质上，通过从尺寸排阻色谱基质中去除蛋白结合的目标分析物来分离游离的目标分析物和蛋白结合的分析物，并用有机溶剂从尺寸排阻色谱基质中洗脱游离的目标分析物。
• SHIMIZU, MASATO;TAKAHASHI, TOMOHIKO;URATSUKA, SATORU;YAMADA, SACHIKO, J. CHEM. SOC. CHEM. COMMUN.,(1990) N0, C. 1416-1417
  作者：SHIMIZU, MASATO、TAKAHASHI, TOMOHIKO、URATSUKA, SATORU、YAMADA, SACHIKO

  DOI：——

  日期：——
• SEPARATING AND QUANTIFYING UNBOUND TARGET ANALYTES FROM BIOLOGICAL SAMPLES
  申请人：ARUP Laboratories, Inc

  公开号：US20190329153A1

  公开（公告）日：2019-10-31

  A method of separating free target analyte from protein-bound target analyte is described. Such can include obtaining an aqueous sample containing a target analyte in a free form (free target analyte) and the target analyte in a protein-bound form (protein-bound target analyte), passing the aqueous sample through a size exclusion chromatography matrix with a molecular weight cut off sufficient to allow the free target analyte to permeate into pores of the size exclusion chromatography matrix and exclude the protein-bound target analyte, whereupon the free target analyte adheres to and is immobilized by the size exclusion chromatography matrix and the protein-bound target analyte does not adhere to by the size exclusion chromatography matrix, separating the free target analyte from the protein-bound analyte by removing the protein-bound target analyte from the size exclusion chromatography matrix, and eluting the free target analyte from the size exclusion chromatography matrix with an organic solvent.
• Synthesis of highly fluorescent dienophiles for detecting conjugated dienes in biological fluid
  作者：Masato Shimizu、Tomohiko Takahashi、Satoru Uratsuka、Sachiko Yamada

  DOI：10.1039/c39900001416

  日期：——

  Fluorigenic dienophiles, 1,2,4-triazoline-3,5-dione derivatives with a highly fluorescent substituent at the 4-position 1a, b, were synthesized as reagents for detecting biological compounds with a conjugated diene group.

  具有高荧光取代基的氟源二烯亲体，1,2,4-三氮唑-3,5-二酮衍生物1a、b被合成作为检测带有共轭二烯基的生物化合物的试剂。