1-[2-(1H-imidazol-1-yl)pyrimidin-4-yl]-N-[2-(3-methoxyphenyl)ethyl]pyrrolidine-2-carboxamide | 212648-45-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1-[2-(1H-imidazol-1-yl)pyrimidin-4-yl]-N-[2-(3-methoxyphenyl)ethyl]pyrrolidine-2-carboxamide
• 英文别名: 1-(2-imidazol-1-ylpyrimidin-4-yl)-N-[2-(3-methoxyphenyl)ethyl]pyrrolidine-2-carboxamide
• CAS: 212648-45-8
• 化学式: C₂₁H₂₄N₆O₂
• 分子量: 392.461
• InChiKey: QOLZMAGKTWBBGQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  85.2
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• N-heterocyclic derivatives as NOS inhibitors
  申请人：Berlex Laboratories, Inc.

  公开号：US20020183323A1

  公开（公告）日：2002-12-05

  N-Heterocyclic derivatives of the formula (I): 1 are described herein, as well as other N-heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using these compounds as inhibitors of nitric oxide synthase and processes for synthesizing these compounds are also described herein.

  本文描述了公式（I）中的N-杂环衍生物1，以及其他N-杂环，作为一氧化氮合酶的抑制剂。本文还描述了含有这些化合物的制药组合物，使用这些化合物作为一氧化氮合酶抑制剂的方法，以及合成这些化合物的过程。
• N-Heterocyclic derivatives as nos inhibitors
  申请人：Berlex, Inc.

  公开号：EP1754703A2

  公开（公告）日：2007-02-21

  N-Heterocyclic derivatives of formula (I) are described herein, as well as other N-Heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using these compounds as inhibitors of nitric oxide synthase and processes for synthesizing these compounds are also described herein.

  本文描述了作为一氧化氮合酶抑制剂的式 (I) N-杂环衍生物以及其他 N-杂环。本文还描述了含有这些化合物的药物组合物、使用这些化合物作为一氧化氮合酶抑制剂的方法以及合成这些化合物的工艺。
• Coordinative alignment of molecules in chiral metal-organic frameworks
  申请人：The Regents of the University of California

  公开号：US11370805B2

  公开（公告）日：2022-06-28

  Coordinative alignment uses x-ray diffraction to precisely and unambiguously determine the structure of molecules bound or crystallized within chiral metal organic frameworks.

  协调配准利用 X 射线衍射来精确无误地确定手性金属有机框架内结合或结晶的分子结构。
• Building material comprising a fibrous or filament reinforcement
  申请人：——

  公开号：US20030176593A1

  公开（公告）日：2003-09-18

  The invention concerns a building material with hydraulic binder comprising a fibrous or filament reinforcement. The reinforcement consists of synthetic yarns and fibres, modified by a dendritic polymer. The invention concerns for example fibre cements whereof the reinforcing fibers consist of a composition comprising a polyamide and a dendritic polymer.

  本发明涉及一种带有液压粘结剂的建筑材料，其中包括纤维或丝状增强材料。加固材料由经树枝状聚合物改性的合成纱线和纤维组成。例如，本发明涉及纤维水泥，其中的增强纤维由聚酰胺和树枝状聚合物组成。
• Stripper formulations and process
  申请人：Scherubel A. Gary

  公开号：US20050233927A1

  公开（公告）日：2005-10-20

  Improved stripper formulations for use on metal cross linked floor finishes comprise a compound selected from the group consisting of a chelant containing an amine functionality and a metal chelating ligand, an alkali metal salt of the chelant, an aliphatic or aromatic polyamine, the aromatic polyamine having the amine functionality outside the aromatic ring, and mixtures of the chelant and polyamine. The stripper formulations are applied to metal cross linked floor finishes in a process for stripping such finishes.

  用于金属交联地板饰面的改进型剥离剂配方包含一种选自以下组别的化合物：含有胺官能团和金属螯合配体的螯合剂、螯合剂的碱金属盐、脂肪族或芳香族多胺（芳香族多胺在芳香环之外具有胺官能团）以及螯合剂和多胺的混合物。剥离剂配方可在剥离金属交联地板饰面的工艺中用于此类饰面。