6-methyl-pyridine-2-carboxylic acid {(S)-2-(1H-indol-3-yl)-1-methyl-1-[(1-pyridin-2-yl-cyclohexylmethyl)-carbamoyl]-ethyl}-amide | 425640-09-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 6-methyl-pyridine-2-carboxylic acid {(S)-2-(1H-indol-3-yl)-1-methyl-1-[(1-pyridin-2-yl-cyclohexylmethyl)-carbamoyl]-ethyl}-amide
• 英文别名: N-[(2S)-3-(1H-indol-3-yl)-2-methyl-1-oxo-1-[(1-pyridin-2-ylcyclohexyl)methylamino]propan-2-yl]-6-methylpyridine-2-carboxamide
• CAS: 425640-09-1
• 化学式: C₃₁H₃₅N₅O₂
• 分子量: 509.651
• InChiKey: XJOIFVWSLSXDES-PMERELPUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  38
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  99.8
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• TREATMENT OF SEXUAL DYSFUNCTION
  申请人：Warner-Lambert Company LLC

  公开号：EP1333824A2

  公开（公告）日：2003-08-13
• [EN] TREATMENT OF SEXUAL DYSFUNCTION<br/>[FR] TRAITEMENT DE DYSFONCTIONNEMENTS SEXUELS
  申请人：WARNER LAMBERT CO

  公开号：WO2002040008A2

  公开（公告）日：2002-05-23

  Bombesin receptor antagonists have been found to be useful in the treatment of sexual dysfunction in both males and females. They may be selective BB1 antagonists or mixed BB1/BB2 antagonists. Combinations are disclosed of bombesin receptor antagonists with a range of other active compounds, for example PDE5 inhibitors, NEP inhibitors and lasofoxifene.