phenyl[N-(R,S)-[N-(S)-benzyloxycarbonylphenylalaninyl]-1-aminophenylmethyl]phosphinic acid | 1242584-17-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: phenyl[N-(R,S)-[N-(S)-benzyloxycarbonylphenylalaninyl]-1-aminophenylmethyl]phosphinic acid
• CAS: 1242584-17-3
• 化学式: C₃₀H₂₉N₂O₅P
• 分子量: 528.544
• InChiKey: GTPLMQDHQRWWDC-BVOOQYFDSA-N

反应信息

• 作为产物：
  描述：

  在 水 作用下， 以 乙腈 为溶剂， 反应 12.0h， 生成 phenyl[N-(R,S)-[N-(S)-benzyloxycarbonylphenylalaninyl]-1-aminophenylmethyl]phosphinic acid
  参考文献：
  名称：

  Direct synthesis of phosphinopeptides containing C-terminal α-aminoalkylphosphinic acids

  摘要：

  A series of phosphinopeptides containing C-terminal alpha-aminoalkylphosphinic acids were prepared in good yields directly in one-pot reactions of 2-(N-benzoxycarbonylamino)alkanamides/peptide amides, aldehydes, and aryldichlorophosphines, followed by hydrolysis. In the current method, the peptide bond was formed in a Mannich-type reaction.

  DOI：

  10.1007/s00726-009-0469-7