trans-Diketo-6,12-hexahydro-4b,5,6,10b,11,12-chrysen | 50637-52-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: trans-Diketo-6,12-hexahydro-4b,5,6,10b,11,12-chrysen
• 英文别名: 6.12-dioxo-trans-4b.5.6.10b.11.12-hexahydro-chrysene；6.12-Dioxo-trans-4b.5.6.10b.11.12-hexahydro-chrysen；(4bS,10bR)-4b,5,10b,11-tetrahydrochrysene-6,12-dione
• CAS: 50637-52-0
• 化学式: C₁₈H₁₄O₂
• 分子量: 262.308
• InChiKey: QXNOHQMRONMROP-IYBDPMFKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  20
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  trans-Diketo-6,12-hexahydro-4b,5,6,10b,11,12-chrysen 生成 (4bR,10bS)-2,8-Diamino-4b,5,10b,11-tetrahydro-chrysene-6,12-dione
  参考文献：
  名称：

  Dann,O. et al., Justus Liebigs Annalen der Chemie, 1973, p. 1112 - 1140

  摘要：

  DOI：
• 作为产物：
  描述：

  meso-3,4-Diphenyl-adipinsaeure 在 硫酸 作用下， 生成 trans-Diketo-6,12-hexahydro-4b,5,6,10b,11,12-chrysen
  参考文献：
  名称：

  调查。关于β，β'-二苯基-己二酸的衍生物

  摘要：

  I.二苯基-己二酸的硝化和相对困难的卤化产生对，p′-二取代的酸。其他异构体只能少量检测到。对，对′-二氨基-二苯基-己二酸可以用来代表酸性羊毛染料。当试图硫化二苯基己二酸时，通过除去水形成了异构的二酮-六氢-瓜类。

  DOI：

  10.1002/hlca.19490320509

文献信息

• Schuetz; Meyer; Kraetzer, Arzneimittel-Forschung/Drug Research, 1969, vol. 19, # 1, p. 69 - 75
  作者：Schuetz、Meyer、Kraetzer

  DOI：——

  日期：——
• 346. Symmetrical derivatives of chrysene. Part II. Elimination of methyl groups during dehydrogenation in an attempt to prepare 1 : 10-dimethylchrysene
  作者：W. Elwyn Jones、G. R. Ramage

  DOI：10.1039/jr9380001853

  日期：——
• v. Braun; Irmisch, Chemische Berichte, 1931, vol. 64, p. 2461,2464
  作者：v. Braun、Irmisch

  DOI：——

  日期：——
• The role of M cells in mucosal immunity
  作者：L. J. Hathaway、J.-P. Kraehenbuhl*

  DOI：10.1007/pl00000693

  日期：2000.2

  Mucosa-associated lymphoid tissue in the respiratory and digestive tracts are covered by a specialized epithelium, the follicle-associated epithelium, which includes M cells, which are specialized for the uptake and transcytosis of macromolecules and microorganisms. Following transcytosis, antigens are released to cells of the immune system in lymphoid aggregates beneath the epithelium where antigen processing and presentation and stimulation of specific B and T lymphocytes are achieved. Circulation of the lymphoid cells enables their homing to their original, and other, mucosal sites where they exert the effector function. Such a response may be dominated by secretory immunoglobulin A release and may include cytotoxic T lymphocyte action. Binding of particles to the apical M cell membrane may be nonspecific or due to specific interaction between molecules such as integrins and lectins. Exploiting the specific binding to M cells is an aim for mucosal vaccination, for example to increase the efficiency of uptake of an oral vaccine by its conjugation to an M-cel-specific molecule. Alternatively, an M-cell-specific live vector, such as attenuated Salmonella bacteria, may be used to deliver epitopes of other organisms. Mucosal vaccination efficiency may also be enhanced by a temporary increase in the number of M cells.Therefore, investigation of the properties and ontogeny of M cells must be pursued to allow the development of better mucosal vaccines for the future.
• 340. Experiments on the synthesis of substances related to the sterols. Part IV. Some derivatives of chrysene (contd.)
  作者：H. J. Lewis、G. R. Ramage、Robert Robinson

  DOI：10.1039/jr9350001412

  日期：——