2-[2-(dimethylamino)ethyl]-11-{[(1Z)-(6-nitro-1,3-benzodioxol-5-yl)methylene]amino}-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione | 1044939-15-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 2-[2-(dimethylamino)ethyl]-11-{[(1Z)-(6-nitro-1,3-benzodioxol-5-yl)methylene]amino}-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione
• CAS: 1044939-15-2
• 化学式: C₂₈H₂₂N₄O₆
• 分子量: 510.506
• InChiKey: KFYBPUDTWZQZRH-NUJZUDFISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.54
• 重原子数：
  38.0
• 可旋转键数：
  6.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  114.58
• 氢给体数：
  0.0
• 氢受体数：
  8.0

文献信息

• Azonafide derivatives, methods for their production and pharmaceutical compositions therefrom
  申请人：Unibioscreen S.A.

  公开号：EP1787985A1

  公开（公告）日：2007-05-23

  Azonafide derivatives are obtained by reacting azonafide with aldehydes, acyl halides, thioacyl halides, monoisocyanates, isothiocyanates or polyamines, and are useful as active ingredients of pharmaceutical compositions for the treament of cell proliferative disorders.

  Azonafide衍生物是通过将azonafide与醛类、酰卤、硫酰卤、单异氰酸酯、异硫氰酸酯或多胺反应而得到的，它们可作为药物组合物的有效成分，用于治疗细胞增殖性疾病。
• Azonafide Derivatives, Methods for Their Production and Pharmaceutical Compositions Therefrom
  申请人：Van Quaquebeke Eric

  公开号：US20080292585A1

  公开（公告）日：2008-11-27

  Azonafide derivatives are obtained by reacting azonafide with aldehydes, acyl halides, thioacyl halides, monoisocyanates, isothiocyanates, sulfonyl halides, monohalogenoalkanes, monohalogenoalkenes or monohalogenoalkynes, and are useful as active ingredients of pharmaceutical compositions for the prevention and treatment of cell proliferative disorders, in particular several forms of Cancer.

  Azonafide衍生物是通过将azonafide与醛类、酰卤、硫酰卤、单异氰酸酯、异硫氰酸酯、磺酰卤、单卤代烷烃、单卤代烯烃或单卤代炔烃反应得到的，并且它们可用作制药组合物的活性成分，用于预防和治疗细胞增殖性疾病，特别是几种癌症。
• US7741337B2
  申请人：——

  公开号：US7741337B2

  公开（公告）日：2010-06-22