4-vinylphenylcyanamide | 96388-70-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-vinylphenylcyanamide
• 英文别名: (4-Ethenylphenyl)cyanamide
• CAS: 96388-70-4
• 化学式: C₉H₈N₂
• 分子量: 144.176
• InChiKey: LHAUESSGZQDMBD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  35.8
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-vinylphenylcyanamide 在 ammonium hydroxide 、 sodium hydride 作用下， 以 四氢呋喃 、 mineral oil 为溶剂， 反应 0.5h， 生成 1-(4-vinyl-phenyl) 2-iminohydantoin
  参考文献：
  名称：

  Novel and green protocol for the synthesis of 2-iminohydantoins

  摘要：

  A novel and green protocol for the synthesis of N-1 and C-5 substituted 2-iminohydantoins has been developed. Methyl N-cyano-N-alkyl/aryl-aminoacetate reacts with aqueous ammonia at room temperature in 10-30 min. The developed protocol does not require any work-up for the isolation or purification of the products; simple filtration can lead to the pure products in good to excellent yields. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.09.057
• 作为产物：
  描述：

  溴化氰 、 4-乙烯苯胺 以 乙醚 为溶剂， 生成 4-vinylphenylcyanamide
  参考文献：
  名称：

  Novel and green protocol for the synthesis of 2-iminohydantoins

  摘要：

  A novel and green protocol for the synthesis of N-1 and C-5 substituted 2-iminohydantoins has been developed. Methyl N-cyano-N-alkyl/aryl-aminoacetate reacts with aqueous ammonia at room temperature in 10-30 min. The developed protocol does not require any work-up for the isolation or purification of the products; simple filtration can lead to the pure products in good to excellent yields. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.09.057

文献信息

• The synthesis of arylcyanamides: a copper-catalyzed consecutive desulfurization and C–N cross-coupling strategy
  作者：S. N. Murthy Boddapati、Naresh Polam、Baby Ramana Mutchu、Hari Babu Bollikolla

  DOI：10.1039/c7nj03527f

  日期：——

  A one pot highly efficient and simple protocol for the construction of aromatic cyanamides from thioureaviadesulphurization/C–N cross coupling using a cheap, readily available and air stable copper source as a catalyst has been described.

  一种高效简便的一锅法协议用于从硫脲经过脱硫/碳氮交叉偶联构建芳香基氰胺，使用廉价、易得和空气稳定的铜源作为催化剂。