5-Benzyl-[1,2,4]oxadiazole-3-carboxylic acid amide | 19706-08-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 5-Benzyl-[1,2,4]oxadiazole-3-carboxylic acid amide
• 英文别名: 5-Benzyl-1,2,4-oxadiazole-3-carboxamide
• CAS: 19706-08-2
• 化学式: C₁₀H₉N₃O₂
• 分子量: 203.2
• InChiKey: NGAWGGJRPRIGNP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  82
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• INDOLE AMIDE DERIVATIVES AND RELATED COMPOUNDS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES
  申请人：reMYND

  公开号：US20140066457A1

  公开（公告）日：2014-03-06

  This invention provides novel compounds and the novel compounds for use as a medicine, more in particular for the prevention or treatment of neurodegenerative disorders, more specifically certain neurological disorders, such as disorders collectively known as tauopathies, and disorders characterized by cytotoxic α-synuclein amyloidogenesis. The present invention also relates to the use of said novel compounds for the manufacture of medicaments useful for treating such neurodegenerative disorders. The present invention further relates to pharmaceutical compositions including said novel compounds and to methods for the preparation of said novel compounds.

  该发明提供了新型化合物以及用于药物的新型化合物，更具体地用于预防或治疗神经退行性疾病，更具体地是某些神经疾病，如被称为tau病变和细胞毒性α-突触核蛋白淀积症的疾病。本发明还涉及使用所述新型化合物制备用于治疗此类神经退行性疾病的药物。本发明还涉及包括所述新型化合物的制药组合物以及制备所述新型化合物的方法。