4-ethyl-1-hexanol | 66576-32-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 4-ethyl-1-hexanol
• 英文别名: 4-ethylhexan-1-ol
• CAS: 66576-32-7
• 化学式: C₈H₁₈O
• 分子量: 130.23
• InChiKey: RLGDVTUGYZAYIX-UHFFFAOYSA-N

物化性质

• 沸点：
  96 °C(Press: 20 Torr)
• 密度：
  0.821±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  9
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-ethyl-1-hexanol 在 potassium carbonate 、 三乙胺 、 potassium iodide 作用下， 以 乙酸乙酯 、 乙腈 为溶剂， 生成
  参考文献：
  名称：

  J-104129, a novel muscarinic M3 receptor antagonist with high selectivity for M3 over M2 receptors

  摘要：

  A new class of 4-acetamidopiperidine derivatives has been synthesized and investigated for human muscarinic receptor subtype selectivity. Introduction of a hydrocarbon chain of appropriate length into the piperidine nitrogen of the racemic N-(piperidin-4-yl)-2-cyclobutyl-2-hydroxy-2-phenylacetamide platform conferred up to 70-fold selectivity for human muscarinic M-3 receptors over M-2 receptors. Subsequent synthetic derivatizations resulted in highly potent M-3 receptor antagonists with selectivity greater than two orders of magnitude for M-3 over M-2 receptors, from which the analogue 4r was selected. Preparation of both enantiomers of 4r led to the identification of (2R)-N-[1-(4-methyl-3-pentenyl)piperidin-4-yl]-2-cyclopentyl-2-hydroxy-2-phenylacetamide (J-104129, (R)-4r), which exhibited 120-fold selectivity for Mg receptors (K-i = 4.2 nM) over M-2 receptors (K-i = 490 nM). In isolated rat trachea, (R)-4r potently and specifically antagonized acetylcholine (ACh)-induced responses with a K-B value of 3.3 nM. The highly subtype-selective profile was also seen in isolated rat tissue assays (50-fold) and in anesthetized rats (> 250-fold). Oral administration of J-104129 ((R)-4r) antagonized ACh-induced bronchoconstriction with an ED50 value of 0.58 mg/kg in rats. Thus, J-104129 ((R)-4r) may effectively facilitate bronchodilation in the treatment of obstructive airway disease. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(99)00177-7
• 作为产物：
  描述：

  环氧乙烷 、 alkaline earth salt of/the/ methylsulfuric acid 生成 4-ethyl-1-hexanol
  参考文献：
  名称：

  Prout; Cason, Journal of Organic Chemistry, 1949, vol. 14, p. 134

  摘要：

  DOI：

文献信息

• Dual Rh−Ru Catalysts for Reductive Hydroformylation of Olefins to Alcohols
  作者：Fábio M. S. Rodrigues、Peter K. Kucmierczyk、Marta Pineiro、Ralf Jackstell、Robert Franke、Mariette M. Pereira、Matthias Beller

  DOI：10.1002/cssc.201800488

  日期：2018.7.20

  described. Apart from terminal, di‐ and trisubstituted olefins, for the first time the less active internal C−C double bond of tetrasubstituted alkenes can also be utilized. As an example, 2,3‐dimethylbut‐2‐ene is converted into the corresponding n‐alcohol with high yield (90 %) as well as regio‐ and chemoselectivity (>97 %). Key for this development is the use of a combination of Rh complexes with bulky

  描述了一种促进多米诺加氢甲酰化-还原反应的主动选择性双催化体系。除了末端取代的二，三取代烯烃外，还第一次可以使用四取代烯烃的活性较低的内部CC双键。例如，将2,3-二甲基丁-2-烯转化为相应的正丙醇，产率高（90％），区域和化学选择性（> 97％）。该开发的关键是将Rh配合物与庞大的单亚磷酸酯配体和Ru基Shvo配合物结合使用。可以直接使用多种芳族和脂族烯烃来获得主要为线性的醇。
• OPTICAL RECORDING MEDIUM AND COMPOUND USED FOR THE SAME
  申请人：SHIOZAKI Hiroyoshi

  公开号：US20090306376A1

  公开（公告）日：2009-12-10

  A compound comprising a ring structure including a ring composed of four carbon atoms and two nitrogen atoms and a substituted or unsubstituted amino group bonded to the ring structure.

  一种化合物，包括一个环结构，其中包括由四个碳原子和两个氮原子组成的环，以及与环结构相结合的取代或未取代的氨基团。
• [EN] PROCESS<br/>[FR] PROCÉDÉ
  申请人：PHOSPHAGENICS LTD

  公开号：WO2018112512A1

  公开（公告）日：2018-06-28

  An efficient and commercial phosphorylation process of a complex alcohol, such as secondary and tertiary alcohols, with P4O10 at high temperatures, and a product obtained by the process.

  一种高效商业化的磷酸酯化过程，用于复杂醇类（如二级和三级醇），在高温下使用P4O10，以及该过程得到的产品。
• FULLERENE DERIVATIVE AND n-TYPE SEMICONDUCTOR MATERIAL
  申请人：DAIKIN INDUSTRIES, LTD.

  公开号：US20180282274A1

  公开（公告）日：2018-10-04

  An object of the present invention is to provide a novel fullerene derivative usable in n-type semiconductor materials for organic thin-film solar cells and the like. The object is achieved by a fullerene derivative represented by formula (1) wherein R 1 represents aryl optionally substituted with at least one substituent, R 2 represents an organic group, R 3 represents an organic group, with the proviso that at least one of R 2 and R 3 is alkyl optionally substituted with at least one substituent or alkyl ether optionally substituted with at least one substituent, R 4 represents hydrogen or an organic group, and a ring A represents a fullerene ring.

  本发明的目的是提供一种新型富勒烯衍生物，可用于有机薄膜太阳能电池等n型半导体材料。该目的通过由式（1）表示的富勒烯衍生物实现，其中R1代表芳基，可选择地取代至少一个取代基，R2代表有机基团，R3代表有机基团，但至少R2和R3中的一个是烷基，可选择地取代至少一个取代基或烷基醚，可选择地取代至少一个取代基，R4代表氢或有机基团，环A代表一个富勒烯环。
• [EN] STERICALLY HINDERED AMINE STABILIZER<br/>[FR] AGENT STABILISANT AMINÉ STÉRIQUEMENT ENCOMBRÉ
  申请人：BASF SE

  公开号：WO2011029744A1

  公开（公告）日：2011-03-17

  The present invention relates to oxygen-substituted sterically hindered amines of the formulae I or II: (II), wherein, for example, F2, R3, R5, R6, R8, R9, R11, R12, R13, R14 are n-butyl; Z1 to Z10 are propoxy and R1, R4, R7, R10, R13 are 2,2,6,6-tetramethyl-1 -propoxy-piperidin-4-yl. Compositions comprising compounds of formulae I or Il and an organic material, which is susceptible to oxidative, thermal or light- induced degradation, are further disclosed. Optionally, further additives are contained.

  本发明涉及具有以下式I或II的含氧受位阻胺类化合物：(II)，其中，例如，F2、R3、R5、R6、R8、R9、R11、R12、R13、R14为正丁基；Z1至Z10为丙氧基，R1、R4、R7、R10、R13为2,2,6,6-四甲基-1-丙氧基-哌啶-4-基。还公开了包含具有式I或II的化合物和易于氧化、热降解或光诱导降解的有机材料的组合物。可选地，还包含进一步添加剂。