| 1358772-19-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• CAS: 1358772-19-6
• 化学式: C₂₃H₂₈N₂
• 分子量: 332.489
• InChiKey: GSIAQBZHBGRNHL-RUZIMIPGSA-N

反应信息

• 作为产物：
  描述：

  N-苯基哌嗪 在 N-氯代丁二酰亚胺 、 对甲苯磺酸 作用下， 以 乙醚 、 二氯甲烷 、 甲苯 为溶剂， 反应 26.0h， 生成
  参考文献：
  名称：

  Discovery of a Novel Class of Bicyclo[3.1.0]hexanylpiperazines as Noncompetitive Neuropeptide Y Y1 Antagonists

  摘要：

  A novel class of bicyclo[3.1.0]hexanylpiperazine neuropeptide Y (NPY) Y1 antagonists has been designed and synthesized. Scatchard binding analysis showed these compounds to be noncompetitive with [I-125]PYY binding to the Y1 receptor. The most potent member, 1-((1 alpha,3 alpha,5 alpha,6 beta)-6-(3-ethoxyphenyl)-3-methylbicyclo[3.1.0]hexan-6-yl)-4-phenylpiperazine (2) had an IC50 = 62 nM and displayed excellent oral bioavailability in rat (% F po = 80), as well as good brain penetration (B/P ratio = 0.61). In a spontaneous nocturnal feeding study with male Sprague-Dawley rats, 2 significantly reduced food intake during a 12 h period.

  DOI：

  10.1021/ml200265m