(R)-1-(2-oxo-2-(thiophen-2-yl)ethyl)-3-(2-phenyl-2-(phenylamino)acetoxy)-1-azonia-bicyclo[2.2.2]octane trifluoroacetate | 1233327-26-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (R)-1-(2-oxo-2-(thiophen-2-yl)ethyl)-3-(2-phenyl-2-(phenylamino)acetoxy)-1-azonia-bicyclo[2.2.2]octane trifluoroacetate
• 英文别名: [(3R)-1-(2-oxo-2-thiophen-2-ylethyl)-1-azoniabicyclo[2.2.2]octan-3-yl] 2-anilino-2-phenylacetate;2,2,2-trifluoroacetate
• CAS: 1233327-26-8
• 化学式: C₂F₃O₂*C₂₇H₂₉N₂O₃S
• 分子量: 574.621
• InChiKey: UWNTUFLVRRAKJH-IXDYERJFSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  4.24
• 重原子数：
  40
• 可旋转键数：
  9
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.34
• 拓扑面积：
  124
• 氢给体数：
  1
• 氢受体数：
  10

文献信息

• ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITION THEREOF
  申请人：Caligiuri Antonio

  公开号：US20100173880A1

  公开（公告）日：2010-07-08

  Alkaloid aminoester compounds which act as muscarinic receptor antagonists are useful for the prevention and/or treatment of a broncho-obstructive or inflammatory diseases.

  具有肌碱受体拮抗作用的生物碱氨酯化合物对于预防和/或治疗支气管阻塞性或炎症性疾病是有用的。
• DRY POWDER FORMULATION COMPRISING AN ANTIMUSCARINIC DRUG
  申请人：SCHIARETTI Francesca

  公开号：US20110308519A1

  公开（公告）日：2011-12-22

  The invention provides dry powder formulations suitable for the inhalatory administration by means of a dry powder inhaler, comprising an antimuscarinic drug as active ingredient. The invention also provides processes for the preparation of such a formulation and method for the prevention and/or treatment of a wide range of conditions including respiratory disorders by administering such a formulation.
• US8455646B2
  申请人：——

  公开号：US8455646B2

  公开（公告）日：2013-06-04