3,6-Dihydro-2-methoxy-2H-pyran | 6559-35-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃
• 英文名称: 3,6-Dihydro-2-methoxy-2H-pyran
• 英文别名: 6-Methoxy-5,6-dihydro-2h-pyran；2-methoxy-3,6-dihydro-2H-pyran
• CAS: 6559-35-9
• 化学式: C₆H₁₀O₂
• 分子量: 114.144
• InChiKey: ODQPBJUWJLTNMV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] N-PYRIDINYL ACETAMIDE DERIVATIVES AS WNT SIGNALLING PATHWAY INHIBITORS<br/>[FR] DÉRIVÉS N-PYRIDINYL ACÉTAMIDE COMME INHIBITEURS DE LA OIE DE SIGNALISATION WNT
  申请人：REDX PHARMA PLC

  公开号：WO2016055790A1

  公开（公告）日：2016-04-14

  This invention relates to compounds. More specifically, the invention relates to compounds useful as inhibitors of the Wnt signalling pathway. Specifically, inhibitors of Porcupine (Porcn) are contemplated by the invention. In addition the invention contemplates processes to prepare the compounds and uses of the compounds. The compounds of the invention may therefore be used in treating conditions mediated by the Wnt signalling pathway, for example treating cancer, sarcoma, melanoma, skin cancer, haematological tumors, lymphoma, carcinoma, and leukemia; or enhancing the effectiveness of an anti-cancer treatment.

  这项发明涉及化合物。更具体地，该发明涉及作为Wnt信号通路抑制剂的化合物。具体来说，该发明考虑了Porcupine（Porcn）的抑制剂。此外，该发明考虑了制备这些化合物的过程以及这些化合物的用途。因此，该发明的化合物可用于治疗由Wnt信号通路介导的疾病，例如治疗癌症、肉瘤、黑色素瘤、皮肤癌、血液肿瘤、淋巴瘤、癌症和白血病；或增强抗癌治疗的有效性。
• [EN] N-PYRIDINYL ACETAMIDE DERIVATIVES AS INHIBITORS OF THE WNT SIGNALLING PATHWAY<br/>[FR] DÉRIVÉS DE N-PYRIDYL ACÉTAMIDE UTILISÉS COMME INHIBITEURS DE LA VOIE DE SIGNALISATION WNT
  申请人：REDX PHARMA PLC

  公开号：WO2016055786A1

  公开（公告）日：2016-04-14

  This invention relates to compounds. More specifically, the invention relates to compounds useful as inhibitors of the Wnt signalling pathway. Specifically, inhibitors of Porcupine (Porcn) are contemplated by the invention. In addition the invention contemplates processes to prepare the compounds and uses of the compounds. The compounds of the invention may therefore be used in treating conditions mediated by the Wnt signalling pathway, for example treating cancer, sarcoma, melanoma, skin cancer, haematological tumors, lymphoma, carcinoma, and leukemia; or enhancing the effectiveness of an anti-cancer treatment.

  这项发明涉及化合物。更具体地，该发明涉及作为Wnt信号通路抑制剂的化合物。具体来说，该发明考虑了Porcupine（Porcn）的抑制剂。此外，该发明考虑了制备这些化合物的过程以及这些化合物的用途。因此，该发明的化合物可用于治疗由Wnt信号通路介导的疾病，例如治疗癌症、肉瘤、黑色素瘤、皮肤癌、血液肿瘤、淋巴瘤、癌症和白血病；或增强抗癌治疗的有效性。
• Photocurable blends of 2-Methoxytetrahydropyran and cycloaliphatic epoxides
  申请人：UNION CARBIDE CORPORATION

  公开号：EP0262414A2

  公开（公告）日：1988-04-06

  Radiation-curable compositions comprising combinations of cycloaliphatic epoxides and cyclic ethers such as cycloaliphatic ethers cure rapidly when initiated by photoinitiators which form cationic catalysts when irradiated with e.g., ultraviolet light. The compositions can also contain other ingredients including poly(active hydrogen) compounds, vinyl ethers (linear and cyclic), glycidyl ethers, poly(vinyl halides), and polylactones. Radiation-cured coatings can be prepared from the compositions, using reduced quantities of the photoinitiator.

  辐射固化组合物包含环脂族环氧化物和环醚（如环脂族醚）的组合，在光引发剂的引发下可快速固化，光引发剂在紫外线等照射下可形成阳离子催化剂。组合物还可以含有其他成分，包括聚（活性氢）化合物、乙烯基醚（线性和环状）、缩水甘油醚、聚（乙烯基卤化物）和聚内酯。可以用这些组合物制备辐射固化涂层，并减少光引发剂的用量。
• Protected biotin derivatives
  申请人：ZENECA LIMITED

  公开号：EP0305201A2

  公开（公告）日：1989-03-01

  Processes for the preparation of biotinylated polynucleotides and analogues thereof and protected intermediate products for use in such processes are described and claimed. The processes may be conveniently used in the automated synthesis of biotinylated polynucleotide on a DNA synthesiser. The polynucleotides so prepared may be used as labelled probes e.g. as diagnostic tools for clinical and research uses.

  本发明描述并声称了制备生物素化多核苷酸及其类似物的工艺以及用于此类工艺的受保护中间产物。这些工艺可方便地用于在 DNA 合成器上自动合成生物素化多核苷酸。这样制备的多核苷酸可用作标记探针，如临床和研究用的诊断工具。
• Production of unsaturated cycloaliphatic esters and derivatives thereof
  申请人：UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION

  公开号：EP0520419A2

  公开（公告）日：1992-12-30

  Unsaturated cycloaliphatic esters like higher hydrocarbyl, functionally substituted or polyunsaturated cyclohex-3-ene carboxylates, made directly by cycloaddition of dienes with dienophillic (meth/eth)acrylates, and their derivatives like epoxides and urethanes, provide useful thermal and radiation curable coatings, inks, sealants, adhesives, solvents, acid scavengers, and intermediates for other uses.

  不饱和环脂族酯类，如高烃基、功能取代或多不饱和环己-3-烯羧酸酯，直接通过二烯与嗜二（甲基/乙基）丙烯酸酯的环加成反应制成，其衍生物如环氧化物和聚氨酯，可提供有用的热固化和辐射固化涂料、油墨、密封剂、粘合剂、溶剂、酸清除剂和其他用途的中间体。