4-[4-(4-羟基苯基)庚烷-4-基]苯酚 | 7425-79-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-[4-(4-羟基苯基)庚烷-4-基]苯酚
• 英文名称: 4,4-bis(4-hydroxy phenyl)heptane
• 英文别名: 4,4,Di(p-hydroxyphenyl)-heptane；4,4-Bis-(4-hydroxy-phenyl)-heptan；δ.δ-Bis-(4-oxy-phenyl)-heptan；4,4-Bis(4-hydroxyphenyl)heptane；4-[4-(4-hydroxyphenyl)heptan-4-yl]phenol
• CAS: 7425-79-8
• 化学式: C₁₉H₂₄O₂
• 分子量: 284.398
• InChiKey: MLDIQALUMKMHCC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-[4-(4-羟基苯基)庚烷-4-基]苯酚 在 吡啶 、 sodium hydride 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 生成 [4-[4-[4-[acetyl(methyl)amino]phenyl]heptan-4-yl]phenyl] N,N-diethylcarbamate
  参考文献：
  名称：

  3,3-Diphenylpentane skeleton as a steroid skeleton substitute: Novel inhibitors of human 5α-reductase 1

  摘要：

  We designed and synthesized novel type 1 5 alpha-reductase inhibitors by using 3,3-diphenylpentane skeleton as a substitute for the usual steroid skeleton. 4-(3-(4-(N-Methylacetamido)phenyl)pentan-3-yl)phenyl dibenzylcarbamate (11k) is a competitive 5 alpha-reductase inhibitor with the IC50 value of 0.84 mu M. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.07.039
• 作为产物：
  描述：

  4-庚酮 、 苯酚 在 甲烷磺酸 作用下， 生成 4-[4-(4-羟基苯基)庚烷-4-基]苯酚
  参考文献：
  名称：

  3,3-Diphenylpentane skeleton as a steroid skeleton substitute: Novel inhibitors of human 5α-reductase 1

  摘要：

  We designed and synthesized novel type 1 5 alpha-reductase inhibitors by using 3,3-diphenylpentane skeleton as a substitute for the usual steroid skeleton. 4-(3-(4-(N-Methylacetamido)phenyl)pentan-3-yl)phenyl dibenzylcarbamate (11k) is a competitive 5 alpha-reductase inhibitor with the IC50 value of 0.84 mu M. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.07.039

文献信息

• Method for the preparation of aromatic chloroformates
  申请人：Davis Charles Gary

  公开号：US20060293535A1

  公开（公告）日：2006-12-28

  A method for preparing an aromatic chloroformate comprising, introducing a mixture of at least one aromatic hydroxyl compound, phosgene, at least one solvent, and at least one organic base into a flow reactor to obtain a unidirectionally flowing reaction mixture. The unidirectionally flowing reaction mixture is maintained at a temperature between about 0° C. and about 60° C. to produce a single product stream comprising an aromatic chloroformate.

  一种制备芳香氯甲酸酯的方法包括，将至少一种芳香羟基化合物、光气、至少一种溶剂和至少一种有机碱的混合物引入流动反应器中，以获得单向流动的反应混合物。将单向流动的反应混合物保持在约0°C至约60°C的温度下，以产生包含芳香氯甲酸酯的单一产物流。
• Method for the preparation of aliphatic chloroformates
  申请人：Davis Charles Gary

  公开号：US20060084822A1

  公开（公告）日：2006-04-20

  A method for preparing an aliphatic chloroformate comprising, introducing a mixture of at least one aliphatic hydroxyl compound, phosgene, at least one solvent, and optionally at least one organic base into a flow reactor to obtain a unidirectional flowing reaction mixture. The at least one aliphatic hydroxyl compound comprises at least one aliphatic hydroxyl group. The unidirectional flowing reaction mixture is maintained at a temperature between about 0° C. and about 60° C. to produce a single product stream comprising an aliphatic chloroformate.

  制备脂肪基氯甲酸酯的方法包括，将至少一种脂肪基羟基化合物、光气、至少一种溶剂以及可选的至少一种有机碱的混合物引入流动反应器中，以获得单向流动的反应混合物。至少一种脂肪基羟基化合物包括至少一种脂肪基羟基。将单向流动的反应混合物保持在约0°C至约60°C的温度下，以产生包含脂肪基氯甲酸酯的单一产物流。
• BISPHENOL COMPOSITION CONTAINING AROMATIC ALCOHOL SULFONATE AND METHOD FOR PRODUCING SAME, POLYCARBONATE RESIN AND METHOD FOR PRODUCING SAME, AND BISPHENOL PRODUCTION METHOD
  申请人：MITSUBISHI CHEMICAL CORPORATION

  公开号：US20200190004A1

  公开（公告）日：2020-06-18

  A bisphenol composition including a specific amount of aromatic alcohol sulfonate, and a simple method of producing it are provided. Also provided is a method of producing a polycarbonate resin in which, by using the bisphenol composition including a specific amount of aromatic alcohol sulfonate, melt polymerization reaction can be efficiently allowed to proceed to produce a polycarbonate resin having an excellent color tone. A bisphenol composition including an aromatic alcohol sulfonate at not less than 0.1 ppb by mass with respect to a bisphenol. A method of producing a bisphenol composition, including reacting a ketone or an aldehyde with an aromatic alcohol in the presence of sulfuric acid to produce a bisphenol composition. A method of producing a polycarbonate resin, including producing a polycarbonate resin using the bisphenol composition. A polycarbonate resin including a specific amount of aromatic alcohol sulfonate.

  提供了一种包括特定量芳香醇磺酸盐的双酚类组合物，以及生产该组合物的简单方法。还提供了一种生产聚碳酸酯树脂的方法，通过使用包括特定量芳香醇磺酸盐的双酚类组合物，可以有效地进行熔融聚合反应，生产具有优异色调的聚碳酸酯树脂。一种包括不少于双酚类的质量的0.1 ppb芳香醇磺酸盐的双酚类组合物。一种生产双酚类组合物的方法，包括在硫酸存在下将酮或醛与芳香醇反应以生产双酚类组合物。一种生产聚碳酸酯树脂的方法，包括使用双酚类组合物生产聚碳酸酯树脂。一种包括特定量芳香醇磺酸盐的聚碳酸酯树脂。
• Sulfonated polyaryletherketone-block-polyethersulfone copolymers
  申请人：Brunelle Daniel Joseph

  公开号：US20080004443A1

  公开（公告）日：2008-01-03

  Sulfonated block copolymer suitable for use as proton exchange membranes for fuel cells comprise sulfonated polyaryletherketone blocks and polyethersulfone blocks. The sulfonated polyaryletherketone blocks comprise structural units of formula I wherein R 1 is C 1 -C 10 alkyl, C 3 -C 12 cycloalkyl, C 6 -C 14 aryl, allyl, alkenyl, alkoxy, halo, or cyano; Ar 1 and Ar 2 are each independently C 6 -C 20 aromatic radicals, or Ar 1 and Ar 2 , taken together with an intervening carbon atom, form a bicyclic C 6 -C 20 aromatic radical or a tricyclic C 6 -C 20 aromatic radical; M is H, a metal cation, a non-metallic inorganic cation, an organic cation or a mixture thereof; and a is 0 or an integer from 1 to 4.

  适用于燃料电池质子交换膜的磺化嵌段共聚物包括磺化聚芳醚酮嵌段和聚醚砜嵌段。磺化聚芳醚酮嵌段包括以下结构单位I的结构单元，其中R1是C1-C10烷基，C3-C12环烷基，C6-C14芳基，烯丙基，烯烷基，烷氧基，卤素或氰基；Ar1和Ar2分别是C6-C20芳香基，或Ar1和Ar2连同一个介于碳原子形成一个双环C6-C20芳香基或三环C6-C20芳香基；M为H，金属阳离子，非金属无机阳离子，有机阳离子或它们的混合物；a为0或1至4之间的整数。
• IONICALLY BONDED SALT HAVING REACTIVE GROUP AND THERMOPLASTIC RESIN COMPOSITION CONTAINING SAME
  申请人：NIPPON NYUKAZAI CO., LTD.

  公开号：US20150166474A1

  公开（公告）日：2015-06-18

  [Problem] Provided are an ionically bonded salt having a reactive group which improves the weather resistance of a thermoplastic resin, and a thermoplastic resin composition containing the ionically bonded salt. [Solution] An ionically bonded salt which has a reactive group and is represented by the following Chemical Formula (1) or the following Chemical Formula (2): in Chemical Formulas (1) and (2) above, R 1 and R 2 each independently represent a substituted or unsubstituted linear, branched, or cyclic alkyl group having from 1 to 30 carbon atoms, a substituted or unsubstituted aryl group having from 6 to 30 carbon atoms, or a substituted or unsubstituted arylalkyl group having from 7 to 31 carbon atoms, A is a linear or branched alkylene group having from 2 to 4 carbon atoms, n represents an integer of 0 to 50, and Q1 and Q2 each independently represent at least one kind selected from the group consisting of an ammonium ion having an ethylenically unsaturated bond, an imidazolium ion having an ethylenically unsaturated bond, a pyridinium ion having an ethylenically unsaturated bond, a pyrrolidinium ion having an ethylenically unsaturated bond, a pyrrolinium ion having an ethylenically unsaturated bond, a piperidinium ion having an ethylenically unsaturated bond, a pyrazinium ion having an ethylenically unsaturated bond, a pyrimidinium ion having an ethylenically unsaturated bond, a triazolium ion having an ethylenically unsaturated bond, a triazinium ion having an ethylenically unsaturated bond, a quinolinium ion having an ethylenically unsaturated bond, an isoquinolinium ion having an ethylenically unsaturated bond, an indolinium ion having an ethylenically unsaturated bond, a quinoxalinium ion having an ethylenically unsaturated bond, a piperazinium ion having an ethylenically unsaturated bond, an oxazolinium ion having an ethylenically unsaturated bond, a thiazolinium ion having an ethylenically unsaturated bond, and a morpholinium ion having an ethylenically unsaturated bond.

  提供了一种离子键合盐，具有改善热塑性树脂的耐候性的反应性基团，以及含有该离子键合盐的热塑性树脂组合物。具有以下化学式（1）或以下化学式（2）表示的具有反应性基团的离子键合盐： 在上述化学式（1）和（2）中，R1和R2分别独立表示具有1至30个碳原子的取代或未取代的直链、支链或环烷基基团，具有6至30个碳原子的取代或未取代芳基基团，或具有7至31个碳原子的取代或未取代芳基烷基基团，A表示具有2至4个碳原子的直链或支链烷基基团，n表示0至50的整数，Q1和Q2分别独立表示从具有乙烯不饱和键的氨基离子、具有乙烯不饱和键的咪唑离子、具有乙烯不饱和键的吡啶离子、具有乙烯不饱和键的吡咯烷离子、具有乙烯不饱和键的吡咯离子、具有乙烯不饱和键的哌啶离子、具有乙烯不饱和键的吡嗪离子、具有乙烯不饱和键的嘧啶离子、具有乙烯不饱和键的三唑离子、具有乙烯不饱和键的三唑离子、具有乙烯不饱和键的喹啉离子、具有乙烯不饱和键的异喹啉离子、具有乙烯不饱和键的吲哚啉离子、具有乙烯不饱和键的喹啉啉离子、具有乙烯不饱和键的哌啶啉离子、具有乙烯不饱和键的噁唑啉离子、具有乙烯不饱和键的噻唑啉离子和具有乙烯不饱和键的吗啉啉离子中选择的至少一种的群组。