4-Aza-dibenzcyclohepten | 4940-69-6

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: 4-Aza-dibenzcyclohepten
• 英文别名: 11H-benzo[5,6]cyclohepta[1,2-b]pyridine；4-Azatricyclo[9.4.0.03,8]pentadeca-1(15),3(8),4,6,9,11,13-heptaene
• CAS: 4940-69-6
• 化学式: C₁₄H₁₁N
• 分子量: 193.248
• InChiKey: VVJQGUSMDLABEG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• [EN] PROCESS FOR THE PREPARATION OF LORATADINE<br/>[FR] PROCEDE DE PREPARATION DE LORATADINE
  申请人：MOREPEN LAB LTD

  公开号：WO2004080997A1

  公开（公告）日：2004-09-23

  A process for the production of loratadine chemically known as 8-chloro-11-(1-ethoxycarbonyl-4-piperidylidene)-6,11-dihydro-5H-benzo[5,6]cycloheptal[1,2-B]pyridene has been described. The process comprises reacting a tri-cyclic aromatic ketone with an organometallic compound containing Mg in presence of organic solvent then hydrolyzing and isolating loratadine by conventional methods wherein the reaction between cyclic ketone and the said organometallic compound is effected at a glacial temperature.

  已经描述了一种生产洛拉替丁的过程，化学上称为8-氯-11-(1-乙氧羰基-4-哌啶基)-6,11-二氢-5H-苯并[5,6]环庚[1,2-B]吡啶。该过程包括将三环芳香酮与含镁的有机金属化合物在有机溶剂存在下反应，然后通过常规方法水解和分离洛拉替丁，其中环酮与所述有机金属化合物之间的反应在极低温下进行。
• Novel benzo [5,6] cyclohepta [1,2-b] pyridine derivatives and antiallergic agents comprising same
  申请人：SS PHARMACEUTICAL CO., LTD.

  公开号：EP0495484A1

  公开（公告）日：1992-07-22

  Benzo[5,6]cyclohepta[1,2-b]pyridine derivatives of the following formula: wherein R¹ represents a cyano, carbamoyl, alkylsulfoxy, alkylsulfonyl, tetrazolyl or sulfonic acid group, and R² represents a hydrogen atom, a cyano, phenyl, aralkyl, alkoxycarbonylalkyl, aminoalkylcarbamoylalkyl or lower alkyl group, or a group or -X-R₄, X being an oxygen or sulfur atom, R³ standing for a hydrogen atom or a substituted or unsubstituted lower alkyl, phenyl or aralkyl group, and R⁴ being a substituted or unsubstituted lower alkyl, phenyl or aralkyl group or an aminoalkyl group, and salts thereof. Antiallergic and antihistamic agents containing one of the above derivatives or salts as an active ingredient are also described.

  以下是Benzo[5,6]cyclohepta[1,2-b]pyridine衍生物的化学式：其中R¹代表氰基，氨基甲酰基，烷基磺酸氧基，烷基磺酰基，四氮唑基或磺酸基团，R²代表氢原子，氰基，苯基，芳基烷基，烷氧羰基烷基，氨基烷基甲酰基烷基或低碳基团，或-X-R₄的基团，其中X代表氧或硫原子，R³代表氢原子或取代或未取代的低碳基，苯基或芳基烷基团，R⁴代表取代或未取代的低碳基，苯基或芳基烷基团或氨基烷基团，以及其盐。还描述了含有上述衍生物或盐作为活性成分的抗过敏和抗组胺药物。
• Cyclooctynes for click chemistry
  申请人：Massachusetts Institute of Technology

  公开号：US11377424B1

  公开（公告）日：2022-07-05

  Provided herein are dibenzocyclooctyne compounds useful as reagents in 1,3-dipolar cycloaddition reactions, and methods for their preparation.

  本文提供了二苯并环辛炔化合物，可用作1,3-二极体环加成反应的试剂，并提供了它们的制备方法。
• Benzo(5,6)cyclohepta(1,2-B)pyridine derivatives for the inhibition of farnesyl protein transferase
  申请人：SCHERING CORPORATION

  公开号：EP1156046A1

  公开（公告）日：2001-11-21

  Novel compounds, such as formulae (I) and (II), are disclosed. The compounds are useful for inhibiting the abnormal growth of cells, for inhibiting farnesyl protein transferase, and for treating cancers.

  本研究公开了新型化合物，如式（I）和式（II）。这些化合物可用于抑制细胞的异常生长、抑制法尼酰蛋白转移酶和治疗癌症。
• Fused polycyclic compounds, compositions, methods of manufacture, and their use as PAF antagonists, antihistamines and/or antiinflammatory agents
  申请人：SCHERING CORPORATION

  公开号：EP0339978B1

  公开（公告）日：1996-08-21