N2-Formylguanin | 21323-91-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: N2-Formylguanin
• 英文别名: 2-formylamino-1,7(9)-dihydro-purin-6-one；N2-formylguanine；n2-Formyl guanine；N-(6-oxo-1,7-dihydropurin-2-yl)formamide
• CAS: 21323-91-1
• 化学式: C₆H₅N₅O₂
• 分子量: 179.138
• InChiKey: QBDIHFHQWMGAGC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  99.2
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  巴比妥酸 、 N2-Formylguanin 以 水 为溶剂， 生成 5-[(6-hydroxy-9H-purin-2-ylamino)methylene]pyrimidine-2,4,6-trione
  参考文献：
  名称：

  Design and synthesis of novel nucleobase-based barbiturate derivatives as potential anticancer agents

  摘要：

  Cancer today remains one of the most deadly diseases in the world. In search of novel anticancer agents, a series of newly hybrid molecules were designed and synthesized by combining the structural features of nucleobase and barbiturate derivatives using the concept of green chemistry. This approach was accomplished efficiently using the aqueous medium to give the corresponding products in a high yield. The newly synthesized compounds were characterized by spectral analysis FT-IR, H-1 NMR, C-13-NMR, HMBC, MASS and elemental analysis. Evaluations of these molecules over four cell lines panel of human cancer cells have identified several compounds with significant anticancer activities against one or more cell lines. Compounds TBC and TBA proved to exhibit a wide cytotoxic effect on the tested four cell lines at ( IC50 16-24 mu M) and ( IC50 25-34 mu M), respectively. Other compounds, e. g., 1,3-BA, showed a selective cytotoxicity against HepG2 at 7 mu M. Taken together, this study has led to the development of a convenient, a highly yielded, and an environmentally friendly synthetic method of highly promising leads for cancer fighting.

  DOI：

  10.1007/s00044-013-0683-4
• 作为产物：
  描述：

  甲酸 、 鸟嘌呤 以 水 为溶剂， 生成 N2-Formylguanin
  参考文献：
  名称：

  Design and synthesis of novel nucleobase-based barbiturate derivatives as potential anticancer agents

  摘要：

  Cancer today remains one of the most deadly diseases in the world. In search of novel anticancer agents, a series of newly hybrid molecules were designed and synthesized by combining the structural features of nucleobase and barbiturate derivatives using the concept of green chemistry. This approach was accomplished efficiently using the aqueous medium to give the corresponding products in a high yield. The newly synthesized compounds were characterized by spectral analysis FT-IR, H-1 NMR, C-13-NMR, HMBC, MASS and elemental analysis. Evaluations of these molecules over four cell lines panel of human cancer cells have identified several compounds with significant anticancer activities against one or more cell lines. Compounds TBC and TBA proved to exhibit a wide cytotoxic effect on the tested four cell lines at ( IC50 16-24 mu M) and ( IC50 25-34 mu M), respectively. Other compounds, e. g., 1,3-BA, showed a selective cytotoxicity against HepG2 at 7 mu M. Taken together, this study has led to the development of a convenient, a highly yielded, and an environmentally friendly synthetic method of highly promising leads for cancer fighting.

  DOI：

  10.1007/s00044-013-0683-4

文献信息

• [EN] A PROCESS FOR THE PREPARATION OF 9-(2-HYDROXY)-ETHOXYMETHYL-GUANINE<br/>[FR] PROCEDE DE PREPARATION DE 9-(2-HYDROXY)-ETHOXYMETHYL-GUANINE
  申请人：RECORDATI S.A. CHEMICAL AND PHARMACEUTICAL COMPANY

  公开号：WO1995007281A1

  公开（公告）日：1995-03-16

  (EN) A process for the preparation of acyclovir by alkylation of N2-formylguanine with 2-oxa-1,4-diacyloxybutane and hydrolysis of the resulting intermediate is described.(FR) Procédé de préparation d'acyclovir par alkylation de N2-formylguanine au moyen de 2-oxa-1,4-diacyloxybutane et par hydrolyse de l'intermédiaire obtenu.

  一种通过使用2-氧杂-1,4-二酰氧丁烷对N2-甲酰鸟嘌呤进行烷基化反应，并对所得的中间体进行水解制备阿昔洛韦的工艺被描述。
• SCAFFOLDING MATERIAL FOR STEM CELL CULTURES AND STEM CELL CULTURE METHOD USING SAME
  申请人：SEKISUI CHEMICAL CO., LTD.

  公开号：EP3733835A1

  公开（公告）日：2020-11-04

  A scaffolding material for culturing a stem cell, which contains a synthetic resin, and has a storage elasticity at 100°C of 1.0 × 104 Pa or more and 1.0 × 108 Pa or less, and a ratio between the storage elasticity at 25°C and the storage elasticity at 100°C ((storage elasticity at 25°C)/(storage elasticity at 100°C)) of 1.0 × 101 or more and 1.0 × 105 or less. The scaffolding material for stem cell culture has suitable hydrophilicity and strength, high fixation of stem cells after seeding, highly efficient cell proliferation, and excellent scratch resistance.

  一种用于培养干细胞的支架材料，它含有一种合成树脂，并具有以下特性 100°C 时的储存弹性大于或等于 1.0 × 104 Pa，小于或等于 1.0 × 108 Pa，25°C 时的储存弹性与 100°C 时的储存弹性之比（（25°C 时的储存弹性）/（100°C 时的储存弹性））大于或等于 1.0 × 101，小于或等于 1.0 × 105。用于干细胞培养的支架材料具有合适的亲水性和强度，播种后干细胞固定性高，细胞增殖效率高，抗划伤性好。
• CELL CULTURING SCAFFOLDING MATERIAL AND CELL CULTURING VESSEL
  申请人：SEKISUI CHEMICAL CO., LTD.

  公开号：EP3971200A1

  公开（公告）日：2022-03-23

  Provided is a cell culture scaffold material having excellent extensibility of pseudopodia and excellent cell proliferation. The cell culture scaffold material according to the present invention contains a peptide-conjugated polyvinyl alcohol derivative having a polyvinyl alcohol derivative portion and a peptide portion, and has a hydroxyl value of 1,100 mgKOH/g or less.

  本发明提供了一种细胞培养支架材料，它具有极佳的伪足延伸性和细胞增殖性。根据本发明，细胞培养支架材料含有一种肽键合聚乙烯醇衍生物，该衍生物具有聚乙烯醇衍生物部分和肽部分，羟值为 1 100 mgKOH/g 或更低。
• CELL CULTURE SCAFFOLD MATERIAL, CELL CULTURE VESSEL, CELL CULTURE FIBER AND METHOD FOR CULTURING CELL
  申请人：SEKISUI CHEMICAL CO., LTD.

  公开号：EP3950918A1

  公开（公告）日：2022-02-09

  Provided is a scaffolding material for cell culture having suitable hydrophilicity and strength, high fixation of cells after seeding, and highly efficient cell proliferation. The scaffolding material for cell culture according to the present invention has a dispersion component γd of the surface free energy of 24.5 mJ/m2 or more and less than 45.0 mJ/m2, and a dipole component γp of the surface free energy of 1.0 mJ/m2 or more and less than 20.0 mJ/m2.

  本发明提供了一种用于细胞培养的支架材料，它具有合适的亲水性和强度，播种后细胞固定性高，细胞增殖效率高。根据本发明的细胞培养支架材料，其表面自由能的分散分量γd为24.5 mJ/m2或以上且小于45.0 mJ/m2，表面自由能的偶极分量γp为1.0 mJ/m2或以上且小于20.0 mJ/m2。
• CELL CULTURE SCAFFOLD MATERIAL, CELL CULTURE VESSEL, CELL CULTURE CARRIER, CELL CULTURE FIBER AND CELL CULTURE METHOD
  申请人：SEKISUI CHEMICAL CO., LTD.

  公开号：EP3950925A1

  公开（公告）日：2022-02-09

  Provided is a scaffolding material for cell culture having suitable hydrophilicity and strength, high fixation of cells after seeding, and highly efficient cell proliferation. A scaffolding material for cell culture according to the present invention is one containing a synthetic resin, and having a nitrogen content of the synthetic resin of 0.1% by mass or more and 10% by mass or less.

  本发明提供了一种用于细胞培养的支架材料，它具有适当的亲水性和强度，播种后细胞固定性高，细胞增殖效率高。根据本发明，细胞培养用支架材料是一种含有合成树脂的材料，合成树脂的含氮量为 0.1%（质量百分比）或以上，10%（质量百分比）或以下。