2-[2-[4-(Benzenecarbonothioylsulfanyl)-4-cyanopentanoyl]oxyethoxy]ethyl 4-(benzenecarbonothioylsulfanyl)-4-cyanopentanoate | 1415694-06-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-[2-[4-(Benzenecarbonothioylsulfanyl)-4-cyanopentanoyl]oxyethoxy]ethyl 4-(benzenecarbonothioylsulfanyl)-4-cyanopentanoate
• CAS: 1415694-06-2
• 化学式: C₃₀H₃₂N₂O₅S₄
• 分子量: 628.858
• InChiKey: YKCSNQOTHUWYSI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  41
• 可旋转键数：
  20
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  224
• 氢给体数：
  0
• 氢受体数：
  11

反应信息

• 作为产物：
  描述：

  4-氰基-4-(硫代苯甲酰)戊酸 、 二乙二醇 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以 氯仿 为溶剂， 以55.4%的产率得到2-[2-[4-(Benzenecarbonothioylsulfanyl)-4-cyanopentanoyl]oxyethoxy]ethyl 4-(benzenecarbonothioylsulfanyl)-4-cyanopentanoate
  参考文献：
  名称：

  High Viability of Cells Encapsulated in Degradable Poly(carboxybetaine) Hydrogels

  摘要：

  In this study, we report a degradable poly(carboxybetaine) (pCB) hydrogel, produced via a thiol disulfide exchange reaction for cell encapsulation. A pCB dithiol was synthesized as a cross-linker and reacted with a pyridyl dithiol-containing CB copolymer to form a hydrogel. We evaluated the biocompatibility of the pCB-based hydrogel via encapsulation of three cell types, including NIH3T3 fibroblasts, MG63 osteoblast-like cells, and HepG2 hepatocarcinoma cells. Up to 90% of cells retained their viability in the pCB hydrogel even at low cell-seeding densities under serum-free conditions after a 9-day culture. Results are compared with a degradable poly(ethylene glycol) methacrylate (PEGMA) hydrogel, which showed very low cell viability under serum-free condition after a 3-day culture. We incorporated an RGD peptide into the CB hydrogel using a cysteine-terminated cross-linker, which was shown to promote cell proliferation.

  DOI：

  10.1021/la303390j