1-Benzyl-2-methyl-5-chlorbenzimidazol | 46884-05-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 1-Benzyl-2-methyl-5-chlorbenzimidazol
• 英文别名: 5-Chlor-2-methyl-1-benzyl-benzimidazol；1-benzyl-5-chloro-2-methyl-1H-benzoimidazole；Cambridge id 5119820；1-benzyl-5-chloro-2-methylbenzimidazole
• CAS: 46884-05-3
• 化学式: C₁₅H₁₃ClN₂
• 分子量: 256.735
• InChiKey: ZDSBETPPTITSAF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  17.8
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-Benzyl-2-methyl-5-chlorbenzimidazol 在 selenium(IV) oxide 作用下， 以 1,4-二氧六环 为溶剂， 反应 3.0h， 以70%的产率得到1-Benzyl-5-chlorobenzimidazole-2-carbaldehyde
  参考文献：
  名称：

  Garuti; Ghedini; Leoni, Il Farmaco, 1993, vol. 48, # 11, p. 1531 - 1546

  摘要：

  DOI：
• 作为产物：
  描述：

  N*1*-苄基-4-氯-苯-1,2-二胺 以 甲醇 为溶剂， 反应 1.0h， 生成 1-Benzyl-2-methyl-5-chlorbenzimidazol
  参考文献：
  名称：

  Qayyoom, M. A.; Hanumanthu, P.; Ratnam, C. V, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1982, vol. 21, # 9, p. 883 - 884

  摘要：

  DOI：

文献信息

• Methods and compositions of treating a flaviviridae family viral infection
  申请人：Einav Shirit

  公开号：US20100028299A1

  公开（公告）日：2010-02-04

  Briefly described, embodiments of this disclosure include compounds, pharmaceutical compositions, methods of treating a host infected with a virus from the Flaviviridae family of viruses, methods of inhibiting HCV replication in a host, methods of inhibiting the binding of NS4B polypeptide to the 3′UTR of HCV negative strand RNA in a host, methods of treating liver fibrosis in a host, and the like.

  简要描述，本公开涉及的实施例包括化合物、制药组合物、治疗感染黄病毒科病毒的宿主的方法、抑制宿主中HCV复制的方法、抑制NS4B多肽与HCV负链RNA的3'UTR结合的方法、治疗宿主肝纤维化的方法等。
• METHODS OF TREATING A FLAVIVIRIDAE FAMILY VIRAL INFECTION, COMPOSITIONS FOR TREATING A FLAVIVIRIDAE FAMILY VIRAL INFECTION, AND SCREENING ASSAYS FOR IDENTIFYING COMPOSITIONS FOR TREATING A FLAVIVIRIDAE FAMILY VIRAL INFECTION
  申请人：Quake Stephen R.

  公开号：US20100260717A1

  公开（公告）日：2010-10-14

  Briefly described, embodiments of this disclosure include compositions, pharmaceutical compositions, methods of treating a host infected with a virus from the Flaviviridae family of viruses, methods of identifying a candidate agent for the treatment of hepatitis C virus (HCV) infection, and the like.
• METHODS OF TREATING A FLAVIVIRIDAE FAMILY VIRAL INFECTION AND COMPOSITIONS FOR TREATING A FLAVIVIRIDAE FAMILY VIRAL INFECTION
  申请人：Einav Shirit

  公开号：US20110052536A1

  公开（公告）日：2011-03-03

  Briefly described, embodiments of this disclosure include compositions, pharmaceutical compositions, methods of treating a host infected with a virus from the Flaviviridae family of viruses, methods of treating HCV replication in a host, methods of inhibiting the binding of NS4B polypeptide to the 3′UTR of HCV negative strand RNA in a host, methods of treating liver fibrosis in a host, and the like.
• US8895598B2
  申请人：——

  公开号：US8895598B2

  公开（公告）日：2014-11-25
• US9061010B2
  申请人：——

  公开号：US9061010B2

  公开（公告）日：2015-06-23