1-benzyl-3-(4-fluorophenyl)-N,4-dimethyl-N-tetrahydro-pyran-4-yl-5-(trifluoromethyl)-1H-pyrrole-2-carboxylic acid amide | 1574115-65-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 1-benzyl-3-(4-fluorophenyl)-N,4-dimethyl-N-tetrahydro-pyran-4-yl-5-(trifluoromethyl)-1H-pyrrole-2-carboxylic acid amide
• 英文别名: 1-benzyl-3-(4-fluorophenyl)-N,4-dimethyl-N-(oxan-4-yl)-5-(trifluoromethyl)pyrrole-2-carboxamide
• CAS: 1574115-65-3
• 化学式: C₂₆H₂₆F₄N₂O₂
• 分子量: 474.498
• InChiKey: YNEUPZCXEVCXTD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  34
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  34.5
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• [EN] FLUOROMETHYL-SUBSTITUTED PYRROLE CARBOXAMIDES<br/>[FR] PYRROLE CARBOXAMIDES SUBSTITUÉS PAR UN FLUOROMÉTHYLE
  申请人：GRUENENTHAL GMBH

  公开号：WO2014032801A1

  公开（公告）日：2014-03-06

  The invention relates to pyrrole carboxamides bearing a fluoromethyl- moiety as voltage gated calcium channel blockers, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.

  这项发明涉及带有氟甲基基团的吡咯羧酰胺作为电压门控钙通道阻滞剂，以及含有这些化合物的药物组合物，还涉及这些化合物用于治疗和/或预防疼痛以及其他疾病和/或紊乱。
• FLUOROMETHYL-SUBSTITUTED PYRROLE CARBOXAMIDES
  申请人：GRUNENTHAL GMBH

  公开号：US20140066426A1

  公开（公告）日：2014-03-06

  The invention relates to pyrrole carboxamides bearing a fluoromethyl-moiety as voltage gated calcium channel blockers, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.

  这项发明涉及带有氟甲基基团的吡咯酮羧酰胺作为电压门控钙通道阻滞剂，以及含有这些化合物的药物组合物，还涉及这些化合物用于治疗和/或预防疼痛以及其他疾病和/或紊乱。
• DEVELOPING MEMBER, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC APPARATUS
  申请人：CANON KABUSHIKI KAISHA

  公开号：US20140064797A1

  公开（公告）日：2014-03-06

  A high-quality developing member which excels in filming resistance and excels in leak resistance despite high electroconductivity is provided. The developing member includes an electroconductive substrate, an elastic layer formed on the substrate, and a surface layer which covers a surface of the elastic layer. The surface layer includes a first resin which has, between two adjacent urethane linkages, a structure represented by the structural formula (1) and one or both of structures selected from the group consisting of a structure represented by the structural formula (2) and a structure represented by the structural formula (3), a second resin which has a structure represented by the structural formula (4) and one or both of structures selected from the group consisting of a structure represented by the structural formula (5) and a structure represented by the structural formula (6), and an electronically conductive filler.
• US8798508B2
  申请人：——

  公开号：US8798508B2

  公开（公告）日：2014-08-05
• US9302988B2
  申请人：——

  公开号：US9302988B2

  公开（公告）日：2016-04-05