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2-octyldecanoyl chloride | 147218-81-3

中文名称
——
中文别名
——
英文名称
2-octyldecanoyl chloride
英文别名
——
2-octyldecanoyl chloride化学式
CAS
147218-81-3
化学式
C18H35ClO
mdl
——
分子量
302.928
InChiKey
CLEYAFCDWZYEJV-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

物化性质

  • 沸点:
    357.2±10.0 °C(Predicted)
  • 密度:
    0.905±0.06 g/cm3(Predicted)

计算性质

  • 辛醇/水分配系数(LogP):
    9
  • 重原子数:
    20
  • 可旋转键数:
    15
  • 环数:
    0.0
  • sp3杂化的碳原子比例:
    0.94
  • 拓扑面积:
    17.1
  • 氢给体数:
    0
  • 氢受体数:
    1

反应信息

  • 作为反应物:
    描述:
    2-octyldecanoyl chloride硫代乙酰胺 、 sodium hydroxide 作用下, 以 甲苯 为溶剂, 反应 48.0h, 以2.81 g的产率得到2-octyldecanethioic S-acid
    参考文献:
    名称:
    用于递送核酸的阳离子脂质化合物和组合物及用途
    摘要:
    本发明提供了用于递送核酸的阳离子脂质化合物和组合物及用途。所述化合物如下式(I)所示。本发明还提供了以所述化合物为关键组分的纳米脂质颗粒在核酸递送方面的用途,包含递送载体的组分、制备方法和使用方法。
    公开号:
    CN114380724A
  • 作为产物:
    描述:
    参考文献:
    名称:
    COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS
    摘要:
    该披露涉及新型脂质和相关组合物。纳米粒子组合物包括一种新型脂质以及其他脂质,例如磷脂、结构脂质和PEG脂质。纳米粒子组合物进一步包括治疗和/或预防剂,例如RNA,可用于将治疗和/或预防剂传递到哺乳动物细胞或器官中,例如调节多肽、蛋白质或基因表达。
    公开号:
    US20220409536A1
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文献信息

  • [EN] COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS<br/>[FR] COMPOSÉS ET COMPOSITIONS D'ADMINISTRATION INTRACELLULAIRE D'AGENTS THÉRAPEUTIQUES
    申请人:MODERNATX INC
    公开号:WO2018170306A1
    公开(公告)日:2018-09-20
    The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
    该披露涉及新型脂质和相关组合物。纳米粒子组合物包括一种新型脂质以及额外的脂质,如磷脂、结构脂质和PEG脂质。纳米粒子组合物还包括治疗和/或预防措施,如RNA,在将治疗和/或预防措施传递给哺乳动物细胞或器官方面非常有用,例如,调节多肽、蛋白质或基因表达。
  • Compounds and compositions for intracellular delivery of therapeutic agents
    申请人:ModernaTX, Inc.
    公开号:US10266485B2
    公开(公告)日:2019-04-23
    The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
    本公开的特征是新型脂质和涉及新型脂质的组合物。纳米颗粒组合物包括新型脂质以及磷脂、结构脂质和 PEG 脂质等其他脂质。纳米颗粒组合物进一步包括治疗和/或预防剂,如 RNA,可用于向哺乳动物细胞或器官输送治疗和/或预防剂,以调节多肽、蛋白质或基因表达等。
  • [EN] COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS<br/>[FR] COMPOSÉS ET COMPOSITIONS POUR L'ADMINISTRATION INTRACELLULAIRE D'AGENTS THÉRAPEUTIQUES
    申请人:MODERNATX INC
    公开号:WO2017049245A3
    公开(公告)日:2017-05-18
  • Donor–acceptor interaction-mediated arrangement of hydrogen bonded dimers
    作者:Xiao-Qiang Li、Dai-Jun Feng、Xi-Kui Jiang、Zhan-Ting Li
    DOI:10.1016/j.tet.2004.06.104
    日期:2004.9
    The donor-acceptor interaction-driven supramolecular arrangement of a new series of quadruply hydrogen-bonded homo- and heterodimers have been investigated in chloroform with H-1 NMR and UV-Vis spectroscopy. Two kinds of structurally complementary monomers have been prepared. Monomers 3 and 4 are incorporated with one ureidopyrimidone unit and one electron deficient pyromellitic diimide (PDI) or naphthalene diimide (NDI) unit, respectively, monomers 5 and 6 are incorporated with two ureidopyrimidone units and one PDI or NDI unit, respectively, whereas monomers 7 and 8 consist of one electron rich bis-p-phenylene[34]crown-10 unit and one or two 2,7-diamido-1,6-naphthyridine units, respectively. Compounds 3 and 4 exist exclusively as homodimers, respectively. Adding 1 equiv. of 7 to the solution of 3.3 and 4.4 induced them to partially or fully dissociate to produce heterodimers 3.7 and 4.7 due to intermolecular donor-acceptor interaction and the formation of a new binding mode between the ureidopyrimidone of 3 or 4 and the 2,7-diamido-1,6-naphthyridine unit of 7. Both 5 and 6 exist as cyclic monomer and dimer in chloroform. Adding 1 equiv. of 8 to the solution of 5 or 6 in chloroform caused all the cyclic dimer and most of the cyclic monomer to de-cyclize to form new heterodimers 5.8 and 6.8, respectively. H-1 NMR and UV-vis study revealed that heterodimer 5.8 has a structure in which the PDI of 5 is not threaded through the cavity of the bis-p-phenylene [34] crown-10 unit of 8. In contrast, in addition to the heterodimer similar to 5.8, about 40% of heterodimer 6.8 is generated, in which the PDI of 6 is threaded through the cavity of the bis-p-phenylene[3]crown-10 unit of 8 due to the increased donor-acceptor interaction between NDI and bis-p-phenylene [34] crown-10. Steric hindrance and mismatching of the hydrogen bonding moiety play important roles in the arrangement of the new homo- and heterodimers. (C) 2004 Elsevier Ltd. All rights reserved.
  • Self-assembly of a new series of quadruply hydrogen bonded heterotrimers driven by the donor–acceptor interaction
    作者:Xiao-Qiang Li、Mu-Xin Jia、Xiao-Zhong Wang、Xi-Kui Jiang、Zhan-Ting Li、Guang-Ju Chen、Yi-Hua Yu
    DOI:10.1016/j.tet.2005.07.075
    日期:2005.10
    This paper describes the self-assembly of a new series of heterotrimers in chloroform-d by utilizing the cooperative interaction of hydrogen bonding and donor-acceptor interaction. Compounds 1 and 11, in which an 2-ureido-4[1H]-pyrimidinone unit is connected to 34-crown-10 or 36-crown-10, were used as donor monomer, and 2 and 19, in which an 2-ureido-4[1H]-pyrimidinone unit is connected to NDI, were used as acceptor monomer, while linear compound 4, which contains two diamido-1,8-naphthyridines, was used as template. A large tri-p-(t-butyl)phenylmethoxyl group was introduced to 19 in order to compare its assembling behavior with that of 2. Mixing 4 with dimer 1 (.) 2 caused 1 (.) 2 to fully decompose and to afford 55% of 'in-in'-oriented heterotrimer 1 (.) 4 (.) 2. Adding 4 to the solution of 2 (.) 11 or 11 (.) 19 in chloroform-d also led to full dissociation of the dimers. However, in these systems the 'in-in'-arranged heterotrimer 2 (.) 4 (.) 11 or 11 (.) 4 (.) 19 could be produced exclusively. (c) 2005 Elsevier Ltd. All rights reserved.
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