4-((E)-But-2-enoylamino)-butyric acid | 90087-98-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4-((E)-But-2-enoylamino)-butyric acid
• 英文别名: 4-(But-2-enoylamino)butanoic acid
• CAS: 90087-98-2
• 化学式: C₈H₁₃NO₃
• 分子量: 171.196
• InChiKey: PFMDNXRYSQHUFH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Phosphorylcholine-containing poly(meth)acrylamide-based copolymers
  申请人：Novartis AG

  公开号：US10676608B2

  公开（公告）日：2020-06-09

  The invention is related to a class of hydrophilic poly(meth)acrylamide-based copolymer comprising dangling (i.e., pendant) phosphorylcholine groups and dangling (i.e., pendant) reactive groups or chains each of which comprises one carboxyl group, one thiol group, or one primary or secondary amino group. The hydrophilic copolymers have a relatively high affinity to a base coating of a polyanionic polymer on a medical device or contact lens and are reactive towards azetidinium groups of an azetidinium-containing polymer upon heating. They can find particular use in producing water-soluble highly-branched hydrophilic polymeric material and in producing water gradient contact lenses.

  本发明涉及一类亲水性聚(甲基)丙烯酰胺基共聚物，该共聚物包含悬垂(即垂挂)磷酰胆碱基团和悬垂(即垂挂)反应基团或链，每个反应基团或链包含一个羧基、一个硫醇基团或一个伯氨基或仲氨基。亲水共聚物对医疗器械或隐形眼镜上的聚阴离子聚合物基底涂层具有较高的亲和力，并且在加热时对含氮聚合物的氮杂环丁烷基团具有反应性。它们特别适用于生产水溶性高支化亲水性聚合物材料和水梯度隐形眼镜。
• Contact lenses with a lubricious coating thereon
  申请人：Novartis AG

  公开号：US10962803B2

  公开（公告）日：2021-03-30

  The invention is generally related to a soft contact lens which comprises a hydrogel lens body and a coating of a hydrophilic copolymer thereon and to a method for producing the same. The hydrogel lens body comprises or is made of a polymeric material having 1,2- and/or 1,3-diol moieties, and the hydrophilic copolymer comprises arylborono-containing repeating units each having a boronic acid group. The coating is covalently-attached to the hydrogel lens body through cyclic boronic ester linkages each formed between one boronic acid group and one 1,2-diol or 1,3-diol group. The soft contact lens has a surface lubricity higher than the surface lubricity of the lens body.

  本发明一般涉及一种软性隐形眼镜，它包括一个水凝胶镜片体和一层亲水共聚物涂层，以及生产这种软性隐形眼镜的方法。水凝胶镜片主体包括或由具有 1,2- 和/或 1,3- 二醇分子的聚合物材料制成，亲水共聚物包括含有芳基硼酸的重复单元，每个重复单元具有一个硼酸基团。涂层通过一个硼酸基团和一个 1,2-二醇或 1,3-二醇基团之间形成的环状硼酸酯键共价连接到水凝胶镜片本体上。软性隐形眼镜的表面润滑度高于镜片本体的表面润滑度。
• Poly(meth)acrylamide-based copolymers with carboxyl-terminated pendant chains
  申请人：Novartis AG

  公开号：US10920099B2

  公开（公告）日：2021-02-16

  The invention is related to a class of hydrophilic poly(meth)acrylamide-based copolymers each comprising dangling (i.e., pendant) reactive chains each terminated with a carboxyl group groups and at least 50% by mole of (meth)acrylamide repeating units relative to all repeating units of the hydrophilic poly(meth)acrylamide-based copolymer. The hydrophilic copolymers have a relatively high affinity to a base coating of a polyanionic polymer on a medical device or contact lens and are highly reactive towards azetidinium groups of an azetidinium-containing polymer upon heating. They can find particular use in producing water-soluble highly-branched hydrophilic polymeric material and in producing water gradient contact lenses.

  本发明涉及一类亲水性聚(甲基)丙烯酰胺基共聚物，每种共聚物都包含以羧基基团为末端的悬垂(即悬挂)活性链，以及相对于亲水性聚(甲基)丙烯酰胺基共聚物所有重复单元至少 50%(摩尔)的(甲基)丙烯酰胺重复单元。亲水性共聚物对医疗设备或隐形眼镜上的聚阴离子聚合物基底涂层具有相对较高的亲和力，并且在加热时对含氮聚合物的氮杂环丁烷基团具有较高的反应性。它们特别适用于生产水溶性高支化亲水性聚合物材料和水梯度隐形眼镜。
• PHOSPHORYLCHOLINE-CONTAINING POLY(METH)ACRYLAMIDE-BASED COPOLYMERS
  申请人：ALCON INC.

  公开号：EP3655448A1

  公开（公告）日：2020-05-27
• POLY(METH)ACRYLAMIDE-BASED COPOLYMERS WITH CARBOXYL-TERMINATED PENDANT CHAINS
  申请人：ALCON INC.

  公开号：EP3655446A1

  公开（公告）日：2020-05-27