| 101979-08-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• CAS: 101979-08-2
• 化学式: C₁₉H₂₇N₇O₇
• 分子量: 465.466
• InChiKey: RMEAPTTVWIJSNH-RKLWJJNISA-N

反应信息

• 作为产物：
  描述：

  灰瘟素 在 Aspergillus f lavus IMF 47798 作用下， 反应 144.0h， 以36%的产率得到
  参考文献：
  名称：

  New Metabolic Pathway for Converting Blasticidin S in Aspergillus flavus and Inhibitory Activity of Aflatoxin Production by Blasticidin S Metabolites

  摘要：

  Blasticidin S, a protein synthesis inhibitor, inhibits aflatoxin production of Aspergillus flavus without affecting fungal growth. Analysis of metabolites in blasticidin S-treated A. flavus using quadrupole time-of-flight liquid chromatography mass spectrometry showed that blasticidin S was metabolized into a novel metabolite, N-acetyldeaminohydroxyblasticidin S. Conversion of blasticidin S to N-acetyldeaminohydroxyblasticidin S via deaminohydroxyblasticidin S or N-acetylblasticidin S was observed in in vivo and in vitro A. flavus systems. Blasticidin S and N-acetylblasticidin S inhibited the growth of Aspergillus niger strongly and weakly, respectively, but deaminohydroxyblasticidin S and N-acetyldeaminohydroxyblasticidin S did not inhibit its growth. On the other hand, deaminohydroxyblasticidin S sustained the inhibition of aflatoxin production whereas N-acetylblasticidin S and N-acetyldeaminohydroxyblasticidin S did not. These results suggest that the free amino group at C-13 of blasticidin S and deaminohydroxyblasticidin S may be important for the inhibitory activity of aflatoxin production.

  DOI：

  10.1021/jf402745c